{"id":2117,"date":"2022-11-01T06:22:34","date_gmt":"2022-10-31T21:22:34","guid":{"rendered":"https:\/\/1up-life.blog\/?p=2117"},"modified":"2022-11-01T06:23:38","modified_gmt":"2022-10-31T21:23:38","slug":"%e3%83%90%e3%83%bc%e3%83%86%e3%83%83%e3%82%af%e3%82%b9%e3%83%bb%e3%83%95%e3%82%a1%e3%83%bc%e3%83%9e%e3%82%b7%e3%83%a5%e3%83%bc%e3%83%86%e3%82%a3%e3%82%ab%e3%83%ab%e3%82%bavrtx2022%e5%b9%b4%e7%ac%ac3","status":"publish","type":"post","link":"https:\/\/1up-life.blog\/?p=2117","title":{"rendered":"\u30d0\u30fc\u30c6\u30c3\u30af\u30b9\u30fb\u30d5\u30a1\u30fc\u30de\u30b7\u30e5\u30fc\u30c6\u30a3\u30ab\u30eb\u30ba(VRTX)2022\u5e74\u7b2c3\u56db\u534a\u671f\u6c7a\u7b97\u8aac\u660e\u4f1a"},"content":{"rendered":"

\u30d0\u30fc\u30c6\u30c3\u30af\u30b9\u30fb\u30d5\u30a1\u30fc\u30de\u30b7\u30e5\u30fc\u30c6\u30a3\u30ab\u30eb\u30ba(VRTX)2022\u5e74\u7b2c3\u56db\u534a\u671f\u6c7a\u7b97\u8aac\u660e\u4f1a\u306e\u65e5\u672c\u8a9e\u8a33\u3067\u3059\u3002<\/p>\n

\u597d\u6c7a\u7b97\u3067\u682a\u4fa1\u3082\u6025\u4f38\u3067\u3059\u306d\u3002\u682a\u4fa1\u306f\u524d\u56de\u306e\u9ad8\u5024\u3092\u30d6\u30ec\u30a4\u30af\u30a2\u30a6\u30c8\u3057\u305f\u306e\u3067\u8cb7\u3044\u6642\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u88fd\u54c1\u81ea\u4f53\u3082\u7af6\u4e89\u529b\u304c\u3042\u308a\u9b45\u529b\u7684\u306a\u306e\u3067\u8cb7\u3063\u3066\u3044\u304d\u305f\u3044\u3067\u3059\u306d\u3002<\/p>\n

\"\u30d0\u30fc\u30c6\u30c3\u30af\u30b9\u30fb\u30d5\u30a1\u30fc\u30de\u30b7\u30e5\u30fc\u30c6\u30a3\u30ab\u30eb\u30ba(VRTX)\u682a\u4fa1\"

\u30d0\u30fc\u30c6\u30c3\u30af\u30b9\u30fb\u30d5\u30a1\u30fc\u30de\u30b7\u30e5\u30fc\u30c6\u30a3\u30ab\u30eb\u30ba(VRTX)\u682a\u4fa1<\/p><\/div>\n

\u524d\u56de\u306e2022\u5e74\u7b2c2\u56db\u534a\u671f\u6c7a\u7b97\u8aac\u660e\u4f1a\u306f\u3053\u3061\u3089<\/a>\u3067\u3059\u3002<\/p>\n

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Call participants:
\nSusie Lisa — Senior Vice President of Investor Relations
\nReshma Kewalramani — Chief Executive Officer and President
\nStuart Arbuckle — Chief Operating Officer
\nCharlie Wagner — Chief Financial Officer
\nUnknown speaker
\nMohit Bansal — Wells Fargo Securities — Analyst
\nSalveen Richter — Goldman Sachs — Analyst
\nPhil Nadeau — Cowen and Company — Analyst
\nEvan Seigerman — BMO Capital Markets — Analyst
\nDavid Risinger — SVB Securities LLC — Analyst
\nKripa Devarakonda — Truist Securities — Analyst
\nJessica Fye — J.P. Morgan — Analyst
\nMore VRTX analysis<\/p>\n

2022\u5e7410\u670827\u65e5\u5348\u5f8c4\u664230\u5206\uff08\u7c73\u56fd\u6771\u90e8\u6642\u9593\uff09<\/p>\n

\u30aa\u30da\u30ec\u30fc\u30bf\u30fc<\/p>\n

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\u305d\u308c\u3067\u306f\u3001\u30b9\u30fc\u30b8\u30fc\u30ea\u30b6\u3055\u3093\u306b\u4f1a\u898b\u3092\u5f15\u304d\u7d99\u304e\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

\u30b9\u30fc\u30b8\u30fc\u30ea\u30b6 — \u30a4\u30f3\u30d9\u30b9\u30bf\u30fc\u30ea\u30ec\u30fc\u30b7\u30e7\u30f3\u30ba\u62c5\u5f53\u4e0a\u7d1a\u526f\u793e\u9577
\n\u7686\u3055\u3093\u3001\u3053\u3093\u3070\u3093\u306f\u3002\u79c1\u306f\u30b9\u30fc\u30b8\u30fc\u30ea\u30b5\u3068\u7533\u3057\u307e\u3059\u30022022\u5e74\u7b2c3\u56db\u534a\u671f\u6c7a\u7b97\u306e\u96fb\u8a71\u4f1a\u8b70\u306b\u3088\u3046\u3053\u305d\u3002\u4eca\u591c\u306e\u96fb\u8a71\u3067\u306f\u3001\u6e96\u5099\u306e\u305f\u3081\u3001Reshma Kewalramani\u535a\u58eb\u306b\u3054\u6328\u62f6\u3092\u304a\u9858\u3044\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

Reshma Kewalramani\uff08\u30d0\u30fc\u30c6\u30c3\u30af\u30b9\u793eCEO\u517c\u793e\u9577\uff09\u3001Stuart Arbuckle\uff08\u6700\u9ad8\u57f7\u884c\u8cac\u4efb\u8005\uff09\u3001Charlie Wagner\uff08\u6700\u9ad8\u8ca1\u52d9\u8cac\u4efb\u8005\uff09\u3067\u3059\u3002\u3053\u306e\u96fb\u8a71\u4f1a\u8b70\u3092\u304a\u805e\u304d\u306b\u306a\u308b\u969b\u306b\u306f\u3001\u30a6\u30a7\u30d6\u30ad\u30e3\u30b9\u30c8\u306e\u30b9\u30e9\u30a4\u30c9\u306b\u30a2\u30af\u30bb\u30b9\u3055\u308c\u308b\u3053\u3068\u3092\u304a\u52e7\u3081\u3057\u307e\u3059\u3002\u672c\u901a\u8a71\u306f\u9332\u97f3\u3055\u308c\u3066\u304a\u308a\u3001\u518d\u751f\u306f\u5f53\u793e\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\u306b\u3066\u3054\u89a7\u3044\u305f\u3060\u3051\u307e\u3059\u3002\u3053\u306e\u96fb\u8a71\u4f1a\u8b70\u3067\u306f\u3001\u672c\u65e5\u306e\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u304a\u3088\u3073\u7c73\u56fd\u8a3c\u5238\u53d6\u5f15\u59d4\u54e1\u4f1a\u306b\u63d0\u51fa\u3057\u305f\u66f8\u985e\u306b\u8a73\u8ff0\u3055\u308c\u3066\u3044\u308b\u30ea\u30b9\u30af\u3084\u4e0d\u78ba\u5b9f\u6027\u3092\u524d\u63d0\u3068\u3057\u305f\u3001\u5c06\u6765\u306e\u898b\u901a\u3057\u306b\u95a2\u3059\u308b\u8a18\u8ff0\u3092\u884c\u3046\u4e88\u5b9a\u3067\u3059\u3002
\n\u3053\u308c\u3089\u306e\u8a18\u8ff0\u306f\u3001\u30d0\u30fc\u30c6\u30c3\u30af\u30b9\u304c\u8ca9\u58f2\u3059\u308b\u56a2\u80de\u6027\u7dda\u7dad\u75c7\u6cbb\u7642\u85ac\u3001\u5f53\u793e\u306e\u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u304a\u3088\u3073\u30d0\u30fc\u30c6\u30c3\u30af\u30b9\u306e\u5c06\u6765\u306e\u8ca1\u52d9\u5b9f\u7e3e\u306b\u95a2\u3059\u308b\u3082\u306e\u3092\u542b\u3080\u304c\u3053\u308c\u306b\u9650\u5b9a\u3055\u308c\u305a\u3001\u7d4c\u55b6\u9663\u306e\u73fe\u5728\u306e\u4eee\u5b9a\u306b\u57fa\u3065\u304f\u3082\u306e\u3067\u3042\u308b\u3002\u5b9f\u969b\u306e\u7d50\u679c\u3084\u4e8b\u8c61\u306f\u3001\u5927\u304d\u304f\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u4eca\u6669\u306e\u96fb\u8a71\u4f1a\u8b70\u3067\u691c\u8a0e\u3059\u308b\u4e00\u90e8\u306e\u8ca1\u52d9\u7d50\u679c\u304a\u3088\u3073\u30ac\u30a4\u30c0\u30f3\u30b9\u306f\u3001\u975eGAAP\u30d9\u30fc\u30b9\u3067\u8868\u793a\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u306b\u7559\u610f\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u305d\u308c\u3067\u306f\u3001Reshma\u306b\u96fb\u8a71\u3092\u3064\u306a\u304e\u307e\u3059\u3002<\/p>\n

\u30ec\u30b7\u30e5\u30de\u30fb\u30b1\u30ef\u30e9\u30de\u30cb — \u6700\u9ad8\u7d4c\u55b6\u8cac\u4efb\u8005\u517c\u793e\u9577<\/p>\n

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TRIKAFTA\u306f\u3001\u767b\u9332\u8a66\u9a13\u3060\u3051\u3067\u306a\u304f\u3001\u5b9f\u81e8\u5e8a\u8a66\u9a13\u3084\u9577\u671f\u8a66\u9a13\u306b\u304a\u3044\u3066\u3082\u3001\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u306e\u9762\u3067\u975e\u5e38\u306b\u9ad8\u3044\u30cf\u30fc\u30c9\u30eb\u3092\u8a2d\u5b9a\u3057\u3066\u3044\u307e\u3059\u3002\u3068\u306f\u3044\u3048\u3001CF\u60a3\u8005\u3055\u3093\u306b\u3068\u3063\u3066\u3055\u3089\u306b\u6709\u52b9\u306a\u533b\u85ac\u54c1\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308c\u3070\u3001\u79c1\u305f\u3061\u306f\u305d\u306e\u3088\u3046\u306a\u4f01\u696d\u306b\u306a\u308b\u3053\u3068\u3092\u6c7a\u610f\u3057\u3066\u3044\u307e\u3059\u3002VX-121\/\u30c6\u30b6\u30ab\u30d5\u30bf\u30fc\/VX-561\u306f\u3001\u305d\u306e\u53ef\u80fd\u6027\u3092\u79d8\u3081\u305f\u30cd\u30af\u30b9\u30c8\u30a4\u30f3\u30af\u30e9\u30b9\u306e3\u5264\u4f75\u7528\u7642\u6cd5\u3067\u3059\u3002\u73fe\u5728\u3001vanzacaftor\u3001tezacaftor\u3001deutivacaftor\u307e\u305f\u306fvanzacaftor triple\u3068\u547c\u3070\u308c\u308b\u3053\u306e3\u5264\u4f75\u7528\u7642\u6cd5\u306f\u300112\u6b73\u4ee5\u4e0a\u306e\u60a3\u8005\u3055\u3093\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7b2c3\u76f8\u8a66\u9a13\u3067\u6025\u901f\u306b\u9032\u5c55\u3057\u3066\u304a\u308a\u3001\u672c\u5e74\u4e2d\u306b\u767b\u9332\u304c\u5b8c\u4e86\u3059\u308b\u3068\u4e88\u60f3\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u7d44\u307f\u5408\u308f\u305b\u306f\u3001\u5f53\u793e\u306e\u30d2\u30c8\u6c17\u7ba1\u652f\u4e0a\u76ae\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001TRIKAFTA\u3088\u308a\u3082\u9ad8\u3044\u6d3b\u6027\u3092\u793a\u3057\u3001\u7b2c2\u76f8\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u5f53\u793e\u306e\u3069\u306e\u5148\u884c\u533b\u85ac\u54c1\u3088\u308a\u3082\u9ad8\u3044\u81e8\u5e8a\u7684\u6709\u7528\u6027\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u30011\u65e51\u56de\u306e\u6295\u4e0e\u3068\u3044\u3046\u5229\u4fbf\u6027\u3082\u3042\u308a\u3001\u30ed\u30a4\u30e4\u30ea\u30c6\u30a3\u3082TRIKAFTA\u306e2\u6841\u53f0\u5f8c\u534a\u306b\u5bfe\u3057\u30661\u6841\u53f0\u524d\u534a\u3068\u306a\u308a\u307e\u3059\u3002CFTR\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5168\u304f\u4f5c\u3089\u306a\u30445,000\u4eba\u306e\u60a3\u8005\u3055\u3093\u306b\u5bfe\u3057\u3066\u306f\u3001Moderna\u306e\u30d1\u30fc\u30c8\u30ca\u30fc\u3068\u5171\u540c\u3067mRNA\u7642\u6cd5\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3064\u3044\u3066\u306f\u3001IND\u53d6\u5f97\u306b\u5411\u3051\u305f\u8a66\u9a13\u3092\u5b8c\u4e86\u3057\u3001\u4eca\u56db\u534a\u671f\u4e2d\u306eIND\u63d0\u51fa\u3068\u305d\u306e\u5f8c\u306e\u81e8\u5e8a\u8a66\u9a13\u958b\u59cb\u306b\u5411\u3051\u3066\u9806\u8abf\u306b\u9032\u3093\u3067\u3044\u307e\u3059\u304c\u3001\u307e\u3060\u7d42\u308f\u308a\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

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\u305d\u306e\u305f\u3081\u3001ASH\u3067\u306f\u65b0\u3057\u3044\u81e8\u5e8a\u30c7\u30fc\u30bf\u3092\u767a\u8868\u305b\u305a\u30012023\u5e74\u306e\u524d\u534a\u306b\u6700\u65b0\u306e\u81e8\u5e8a\u30c7\u30fc\u30bf\u3092\u767a\u8868\u3059\u308b\u4e88\u5b9a\u3067\u3059\u3002\u30a8\u30af\u30b5\u30bb\u30eb\u306f\u3001\u91cd\u75c7\u938c\u72b6\u8d64\u8840\u7403\u75c7\u304a\u3088\u3073\u8f38\u8840\u4f9d\u5b58\u6027\u03b2\u30b5\u30e9\u30bb\u30df\u30a2\u306e\u6570\u5343\u4eba\u306e\u60a3\u8005\u3055\u3093\u306b\u3068\u3063\u3066\u3001\u4e00\u5ea6\u3067\u6cbb\u308b\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u6cbb\u7642\u6cd5\u306f\u3001CRISPR\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u7de8\u96c6\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u521d\u3081\u3066\u3001\u907a\u4f1d\u6027\u75be\u60a3\u306e\u60a3\u8005\u3055\u3093\u5411\u3051\u306b\u5546\u696d\u5316\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u8fd1\u3044\u5c06\u6765\u3001\u5927\u304d\u306a\u5e02\u5834\u6a5f\u4f1a\u3092\u3082\u305f\u3089\u3059\u3082\u306e\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002VX-548\u3068\u5f53\u793e\u306e\u75bc\u75db\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u307e\u3059\u3002<\/p>\n

VX-548\u306f\u3001\u65b0\u898f\u306e\u9078\u629e\u7684NaV1.8\u963b\u5bb3\u5264\u3067\u3042\u308a\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u3088\u3046\u306a\u526f\u4f5c\u7528\u3084\u7fd2\u6163\u6027\u306e\u53ef\u80fd\u6027\u3092\u4f34\u308f\u306a\u3044\u3001\u975e\u5e38\u306b\u52b9\u679c\u7684\u306a\u75bc\u75db\u7de9\u548c\u306e\u53ef\u80fd\u6027\u3092\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3067\u3059\u3002NaV1.8\u306f\u3001\u907a\u4f1d\u5b66\u7684\u304a\u3088\u3073\u85ac\u7406\u5b66\u7684\u306b\u691c\u8a3c\u3055\u308c\u305f\u30bf\u30fc\u30b2\u30c3\u30c8\u3067\u3059\u3002VX-150\u306f\u3001\u521d\u671f\u306eNaV1.8\u963b\u5bb3\u5264\u3067\u3042\u308a\u3001\u6025\u6027\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u304a\u3088\u3073\u7b4b\u9aa8\u683c\u7cfb\u75bc\u75db\u306b\u304a\u3044\u3066\u826f\u597d\u306a\u6982\u5ff5\u5b9f\u8a3c\u304c\u306a\u3055\u308c\u305f\u3053\u3068\u3092\u60f3\u8d77\u3057\u3066\u304f\u3060\u3055\u3044\u3002VX-548\u306f\u30012\u3064\u306e\u7b2c2\u76f8\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u6025\u6027\u75bc\u75db\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u7d71\u8a08\u7684\u306b\u6709\u610f\u304b\u3064\u81e8\u5e8a\u7684\u306b\u610f\u5473\u306e\u3042\u308b\u75bc\u75db\u7de9\u548c\u3092\u793a\u3057\u3001\u5168\u822c\u7684\u306b\u826f\u597d\u306a\u5fcd\u5bb9\u6027\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

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\u73fe\u5728\u3001\u7c73\u56fd\u304a\u3088\u3073\u6d77\u5916\u306750\u65bd\u8a2d\u4ee5\u4e0a\u304c\u767b\u9332\u306e\u305f\u3081\u306b\u30aa\u30fc\u30d7\u30f3\u3057\u3066\u304a\u308a\u3001\u5408\u8a08150\u65bd\u8a2d\u4ee5\u4e0a\u306e\u30aa\u30fc\u30d7\u30f3\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u8a66\u9a13\u306e\u9032\u5c55\u306b\u4f34\u3044\u3001\u767b\u9332\u72b6\u6cc1\u3084\u8a66\u9a13\u306e\u9032\u6357\u72b6\u6cc1\u3092\u304a\u77e5\u3089\u305b\u3059\u308b\u3053\u3068\u3092\u697d\u3057\u307f\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u6b21\u306b\u30011\u578b\u7cd6\u5c3f\u75c5\u306b\u3064\u3044\u3066\u3067\u3059\u3002<\/p>\n

\u79c1\u305f\u3061\u306f\u30013\u3064\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u307e\u305a\u3001VX-880\u306f\u3001\u5e79\u7d30\u80de\u7531\u6765\u306e\u5b8c\u5168\u5206\u5316\u578b\u30a4\u30f3\u30b9\u30ea\u30f3\u7523\u751f\u81b5\u5cf6\u7d30\u80de\u88dc\u5145\u7642\u6cd5\u3067\u3001\u81e8\u5e8a\u958b\u767a\u306e\u4e2d\u76e4\u306b\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u306f\u3001\u6a19\u6e96\u7684\u306a\u514d\u75ab\u6291\u5236\u7642\u6cd5\u3092\u7528\u3044\u3066\u3001\u7d30\u80de\u3092\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304b\u3089\u4fdd\u8b77\u3057\u307e\u3059\u3002\u3053\u306e\u540c\u3058\u7d30\u80de\u304c\u30011\u578b\u7cd6\u5c3f\u75c5\u306b\u95a2\u3059\u308b\u4ed6\u306e2\u3064\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u57fa\u790e\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u6b21\u306b\u3001\u7d30\u80de\u30d7\u30e9\u30b9\u30c7\u30d0\u30a4\u30b9\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u3059\u3002\u3053\u306e\u5b8c\u5168\u306b\u5206\u5316\u3057\u305f\u81b5\u5cf6\u7d30\u80de\u3092\u72ec\u81ea\u306e\u30c7\u30d0\u30a4\u30b9\u306b\u5c01\u3058\u8fbc\u3081\u3001\u7d30\u80de\u3092\u4f53\u306e\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304b\u3089\u4fdd\u8b77\u3057\u3001\u514d\u75ab\u6291\u5236\u5264\u3092\u5fc5\u8981\u3068\u3057\u307e\u305b\u3093\u3002\u3053\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3064\u3044\u3066\u306f\u3001\u5e74\u5185\u306eIND\u7533\u8acb\u306b\u5411\u3051\u3066\u9806\u8abf\u306b\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u6700\u5f8c\u306b\u3001\u524d\u81e8\u5e8a\u958b\u767a\u4e2d\u306e\u4f4e\u514d\u75ab\u7d30\u80de\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u306f\u3001\u540c\u3058\u3088\u3046\u306b\u5b8c\u5168\u306b\u5206\u5316\u3057\u305f\u30a4\u30f3\u30b9\u30ea\u30f3\u7523\u751f\u81b5\u5cf6\u7d30\u80de\u3092\u7de8\u96c6\u3057\u3066\u514d\u75ab\u7cfb\u304b\u3089\u906e\u65ad\u3057\u3001\u514d\u75ab\u6291\u5236\u5264\u306e\u5fc5\u8981\u6027\u3092\u306a\u304f\u3059\u3053\u3068\u3092\u8a66\u307f\u3066\u3044\u307e\u3059\u3002\u672c\u5e74\u521d\u3081\u306b\u306f\u3001VX-880\u306e1\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308bProof of Concept\u3092\u9054\u6210\u3057\u3001\u8a66\u9a13\u30d1\u30fc\u30c8A\u306b\u304a\u3044\u3066\u6700\u521d\u306e2\u4eba\u306e\u60a3\u8005\u306b\u534a\u91cf\u3092\u6295\u4e0e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n

\u73fe\u5728\u3001\u76ee\u6a19\u7528\u91cf\u3092\u3059\u3079\u3066\u6295\u4e0e\u3059\u308b\u30d1\u30fc\u30c8B\u8a66\u9a13\u304c\u9032\u884c\u4e2d\u3067\u3042\u308a\u3001\u60a3\u8005\u3055\u3093\u306e\u767b\u9332\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u30021\u578b\u7cd6\u5c3f\u75c5\u30d7\u30ed\u30b0\u30e9\u30e0\u306f\u5927\u304d\u306a\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002\u4f4e\u8840\u7cd6\u306e\u5fc3\u914d\u304c\u306a\u304f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u5fc5\u8981\u3068\u3057\u306a\u3044\u30b0\u30eb\u30b3\u30fc\u30b9\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u671f\u5f85\u3067\u304d\u308b\u6cbb\u7642\u6cd5\u306e\u6069\u6075\u3092\u53d7\u3051\u308b1\u578b\u7cd6\u5c3f\u75c5\u306e\u60a3\u8005\u3055\u3093\u306f\u3001\u7c73\u56fd\u3068EU\u3060\u3051\u3067250\u4e07\u4eba\u4ee5\u4e0a\u3044\u307e\u3059\u3002<\/p>\n

\u3088\u308a\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u3001\u3088\u308a\u9577\u3044\u671f\u9593\u306e\u8ffd\u8de1\u8abf\u67fb\u304b\u3089\u5f97\u3089\u308c\u305f\u8ffd\u52a0\u30c7\u30fc\u30bf\u3092\u3001\u9069\u5207\u306a\u6642\u671f\u306b\u5171\u6709\u3067\u304d\u308b\u3053\u3068\u3092\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002\u6700\u5f8c\u306b\u3001\u5f53\u793e\u306e1\u578b\u7cd6\u5c3f\u75c5\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3064\u3044\u3066\u304a\u8a71\u3057\u307e\u3059\u3002\u6700\u8fd1\u3001Viacyte\u793e\u306e\u8cb7\u53ce\u3092\u5b8c\u4e86\u3057\u307e\u3057\u305f\u306e\u3067\u3001Viacyte\u793e\u306e\u793e\u54e1\u3092\u6e29\u304b\u304f\u8fce\u3048\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u6700\u5f8c\u306b\u3001\u5f53\u793e\u306e\u03b11\u30a2\u30f3\u30c1\u30c8\u30ea\u30d7\u30b7\u30f3\u6b20\u640d\u75c7\uff08AATD\uff09\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3064\u3044\u3066\u304a\u8a71\u3057\u307e\u3059\u3002<\/p>\n

\u4eca\u6708\u521d\u3081\u306b\u306f\u3001\u6b21\u4e16\u4ee3AAT\u88dc\u6b63\u85ac\u306e\u7b2c\u4e00\u5f3e\u3067\u3042\u308bVX-634\u306eIND\u304c\u30af\u30ea\u30a2\u3068\u306a\u308a\u3001VX-634\u304c\u30d2\u30c8\u521d\u81e8\u5e8a\u8a66\u9a13\u3092\u958b\u59cb\u3057\u305f\u3053\u3068\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u5f53\u793e\u306e\u7b2c\u4e00\u4e16\u4ee3AAT\u88dc\u6b63\u85ac\u3067\u3042\u308bVX-864\u306e48\u9031\u9593\u7b2c2\u76f8\u81e8\u5e8a\u8a66\u9a13\u3092\u9593\u3082\u306a\u304f\u958b\u59cb\u3059\u308b\u3053\u3068\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u8a66\u9a13\u3067\u306f\u3001\u9577\u671f\u6295\u4e0e\u306b\u3088\u308b\u809d\u81d3\u304b\u3089\u306e\u30dd\u30ea\u30de\u30fc\u306e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3001\u304a\u3088\u3073\u6a5f\u80fd\u6027AAT\u306e\u8840\u6e05\u30ec\u30d9\u30eb\u3078\u306e\u5f71\u97ff\u3092\u8a55\u4fa1\u3059\u308b\u4e88\u5b9a\u3067\u3059\u3002\u4ee5\u4e0a\u306e\u7814\u7a76\u958b\u767a\u306e\u30cf\u30a4\u30e9\u30a4\u30c8\u3092\u8e0f\u307e\u3048\u3066\u3001\u5546\u696d\u7684\u306a\u9032\u6357\u72b6\u6cc1\u306b\u3064\u3044\u3066\u30b9\u30c1\u30e5\u30a2\u30fc\u30c8\u306b\u8a71\u3092\u8b72\u308d\u3046\u3002<\/p>\n

\u30b9\u30c1\u30e5\u30a2\u30fc\u30c8\u30fb\u30a2\u30fc\u30d0\u30c3\u30af\u30eb — \u6700\u9ad8\u57f7\u884c\u8cac\u4efb\u8005<\/p>\n

\u3042\u308a\u304c\u3068\u3046\u3001\u30ea\u30b7\u30e5\u30de\u3002\u4eca\u591c\u306f\u3001CF\u306e\u597d\u8abf\u3092\u7dad\u6301\u3057\u3001\u307e\u305f\u3001CF\u306b\u304a\u3051\u308b\u5f37\u3044\u898b\u901a\u3057\u3001exa-cel\u306e\u5546\u696d\u7684\u767a\u58f2\u6e96\u5099\u306e\u5927\u304d\u306a\u9032\u5c55\u3001\u75bc\u75db\u6cbb\u7642\u306b\u304a\u3051\u308bVX-548\u306e\u6709\u671b\u306a\u5f79\u5272\u306b\u95a2\u3059\u308b\u6211\u3005\u306e\u898b\u89e3\u306a\u3069\u3001\u6211\u3005\u306e\u4e8b\u696d\u5168\u4f53\u3067\u898b\u3089\u308c\u308b\u8907\u6570\u306e\u77ed\u671f\u5546\u696d\u6a5f\u4f1a\u306b\u3064\u3044\u3066\u30ec\u30d3\u30e5\u30fc\u3067\u304d\u308b\u3053\u3068\u3092\u5b09\u3057\u304f\u601d\u3044\u307e\u3059\u3002\u307e\u305aCF\u304b\u3089\u3067\u3059\u3002\u7c73\u56fd\u3067\u306f\u3001\u5f53\u793e\u306e\u6cbb\u7642\u85ac\u306b\u898b\u3089\u308c\u308b\u975e\u5e38\u306b\u9ad8\u3044\u6301\u7d9a\u6027\u3068\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\u3092\u7dad\u6301\u3057\u3001\u6cbb\u7642\u306e\u52b9\u679c\u3092\u3088\u308a\u82e5\u3044\u5e74\u9f62\u5c64\u307e\u3067\u62e1\u5927\u3059\u308b\u3053\u3068\u306b\u91cd\u70b9\u3092\u7f6e\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u7c73\u56fd\u5916\u3067\u306f\u3001\u511f\u9084\u5354\u5b9a\u304c\u7d50\u3070\u308c\u305f\u56fd\u3005\u3067KAFTRIO\/TRIKAFTA\u306e\u666e\u53ca\u304c\u9032\u307f\u3001\u6025\u6210\u9577\u3092\u9042\u3052\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u30016\u6b73\u304b\u308911\u6b73\u306e\u5c0f\u5150\u306b\u304a\u3051\u308bKAFTRIO\u306e\u4f7f\u7528\u3082\u3001\u3053\u306e\u9069\u5fdc\u75c7\u304c\u4fdd\u967a\u511f\u9084\u3055\u308c\u305f\u56fd\u3005\u3067\u597d\u8abf\u306b\u63a8\u79fb\u3057\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001\u5f53\u793e\u306e\u533b\u85ac\u54c1\u306f30\u30ab\u56fd\u4ee5\u4e0a\u3067\u627f\u8a8d\u30fb\u511f\u9084\u3055\u308c\u3066\u304a\u308a\u30015\u5927\u9678\u3067\u4f55\u4e07\u4eba\u3082\u306e\u56a2\u80de\u6027\u7dda\u7dad\u75c7\u306e\u60a3\u8005\u3055\u3093\u306e\u5f79\u306b\u7acb\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u307e\u3060\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u306a\u3044\u6570\u5343\u4eba\u306eCF\u60a3\u8005\u3055\u3093\u304c\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u308c\u3089\u306e\u60a3\u8005\u3055\u3093\u306f\u3001\u4e3b\u306b\u6b21\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u5206\u985e\u3055\u308c\u307e\u3059\u30021\u3064\u306f\u3001\u6700\u8fd1\u511f\u9084\u5408\u610f\u3084\u82e5\u5e74\u5c64\u306e\u60a3\u8005\u3055\u3093\u3078\u306e\u30e9\u30d9\u30eb\u5ef6\u9577\u3092\u9054\u6210\u3057\u305f\u56fd\u306a\u3069\u3001\u5f53\u793e\u304c\u767a\u58f2\u66f2\u7dda\u306e\u65e9\u3044\u6bb5\u968e\u306b\u3042\u308b\u60a3\u8005\u3055\u3093\u30012\u3064\u306f\u3001\u30e9\u30d9\u30eb\u3084\u511f\u9084\u306e\u5ef6\u9577\u3092\u5f15\u304d\u7d9a\u304d\u8ffd\u6c42\u3057\u3066\u3044\u308b\u82e5\u5e74\u5c64\u306e\u60a3\u8005\u3055\u3093\u30013\u3064\u306f\u3001\u3054\u304f\u5c11\u6570\u306e\u56fd\u3067\u5f53\u793e\u306e\u533b\u85ac\u54c1\u304c\u511f\u9084\u3055\u308c\u308b\u306e\u3092\u5f85\u3063\u3066\u3044\u308b\u60a3\u8005\u3055\u3093\u3001\u306a\u3069\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u60a3\u8005\u3055\u3093\u306e\u5927\u90e8\u5206\u306b\u306f\u3044\u305a\u308c\u5230\u9054\u3067\u304d\u308b\u3068\u78ba\u4fe1\u3057\u3066\u304a\u308a\u3001\u305d\u308c\u304c\u77ed\u671f\u7684\u306b\u3082\u9577\u671f\u7684\u306b\u3082\u7d99\u7d9a\u7684\u306a\u53ce\u76ca\u6210\u9577\u306e\u539f\u52d5\u529b\u306b\u306a\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u5f53\u793e\u306eCFTR\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u306e\u9069\u5fdc\u75c7\u306e\u82e5\u5e74\u5c64\u3078\u306e\u62e1\u5927\u306b\u3064\u3044\u3066\u3082\u3001\u5f15\u304d\u7d9a\u304d\u7d20\u6674\u3089\u3057\u3044\u6210\u679c\u3092\u4e0a\u3052\u3066\u3044\u307e\u3059\u30029\u6708\u306b\u306f\u3001ORKAMBI\u304c\u7c73\u56fd\u3067\u751f\u5f8c12\u30ab\u6708\u304b\u308924\u30ab\u6708\u672a\u6e80\u306e\u5c0f\u5150\u306b\u5bfe\u3059\u308b\u627f\u8a8d\u3092\u53d6\u5f97\u3057\u307e\u3057\u305f\u3002<\/p>\n

KALYDECO\u306b\u3064\u3044\u3066\u306f\u30012022\u5e74\u672b\u307e\u3067\u306b\u3001\u751f\u5f8c1\u30ab\u6708\u304b\u30894\u30ab\u6708\u672a\u6e80\u306e\u5c0f\u5150\u3092\u5bfe\u8c61\u306b\u7c73\u56fdFDA\u306b\u627f\u8a8d\u7533\u8acb\u3059\u308b\u4e88\u5b9a\u3067\u3059\u3002\u540c\u69d8\u306b\u3001TRIKAFTA\u306b\u3064\u3044\u3066\u3082\u30012\u6b73\u4ee5\u4e0a5\u6b73\u672a\u6e80\u306e\u5c0f\u5150\u3092\u5bfe\u8c61\u306b\u5e74\u5185\u306b\u7c73\u56fd\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u4e16\u754c\u306e\u898f\u5236\u5f53\u5c40\u306b\u627f\u8a8d\u7533\u8acb\u3092\u884c\u3046\u4e88\u5b9a\u3067\u3059\u3002<\/p>\n

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\u30b9\u30d4\u30fc\u30ab\u30fc\u4e0d\u660e<\/p>\n

\u3053\u3093\u306b\u3061\u306f\u3001\u30de\u30a4\u30af\u306b\u4ee3\u308f\u3063\u3066\u30c7\u30cb\u30b9\u3067\u3059\u3002\u4eca\u671f\u306e\u9032\u6357\u72b6\u6cc1\u306b\u3064\u3044\u3066\u304a\u3081\u3067\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002\u73fe\u5728\u9032\u884c\u4e2d\u306e\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u306e\u30d5\u30a7\u30fc\u30ba1\u3001VX-880\u306e\u72b6\u6cc1\u306b\u3064\u3044\u3066\u6559\u3048\u3066\u304f\u3060\u3055\u3044\u3002\u307e\u305f\u3001\u4eca\u5e74\u4e2d\u306b\u6700\u65b0\u306e\u30c7\u30fc\u30bf\u304c\u5f97\u3089\u308c\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u307e\u305f\u3001\u305d\u306e\u6642\u671f\u306b\u3064\u3044\u3066\u6559\u3048\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n

\u307e\u305f\u3001\u30c7\u30d0\u30a4\u30b9\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3064\u3044\u3066\u306f\u30012023\u5e74\u306b\u521d\u671f\u30c7\u30fc\u30bf\u3092\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3082\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u307e\u305f\u3001VX-880\u306e\u30d9\u30fc\u30bf\u7248\u304c1\u60a3\u8005\u5206\u3057\u304b\u958b\u793a\u3055\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u304b\u3089\u3001\u305d\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u30c7\u30fc\u30bf\u958b\u793a\u30ec\u30d9\u30eb\u306b\u3064\u3044\u3066\u3069\u306e\u3088\u3046\u306b\u8003\u3048\u308b\u3079\u304d\u3067\u3057\u3087\u3046\u304b\uff1f\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

Reshma Kewalramani — \u6700\u9ad8\u7d4c\u55b6\u8cac\u4efb\u8005\u517c\u793e\u9577<\/p>\n

\u3069\u3046\u3082\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002\u3054\u8cea\u554f\u306f\u3001\u5f53\u793e\u306e1\u578b\u7cd6\u5c3f\u75c5\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3064\u3044\u3066\u3067\u3059\u30021\u578b\u7cd6\u5c3f\u75c5\u306e\u30dd\u30fc\u30c8\u30d5\u30a9\u30ea\u30aa\u306b\u306f\u3001\u5b9f\u306f3\u3064\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u3042\u308a\u307e\u3059\u30021\u3064\u76ee\u306fVX-880\u3067\u3001\u3053\u3061\u3089\u306f\u5b9f\u969b\u306b\u7b2c1\/2\u76f8\u306e\u6bb5\u968e\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u3053\u308c\u306f\u3059\u3067\u306b\u60a3\u8005\u3055\u3093\u304c\u3044\u308b\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u3059\u3002\u3053\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u306f\u3001\u6700\u521d\u306e2\u4eba\u306e\u60a3\u8005\u3055\u3093\u3092\u6cbb\u7642\u3057\u3001\u91cd\u8981\u306a\u3053\u3068\u306b\u76ee\u6a19\u91cf\u306e\u534a\u5206\u306e\u7528\u91cf\u3067\u3001\u3059\u3067\u306b\u6982\u5ff5\u5b9f\u8a3c\u3092\u9054\u6210\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u306f\u73fe\u5728\u3082\u7d99\u7d9a\u4e2d\u3067\u3059\u3002\u73fe\u5728\u3001\u60a3\u8005\u3055\u3093\u3092\u767b\u9332\u3057\u3001\u76ee\u6a19\u7528\u91cf\u3092\u6295\u4e0e\u3057\u3066\u304a\u308a\u3001\u6765\u5e74\u306b\u306f\u9069\u5207\u306a\u4f1a\u8b70\u3084\u4f1a\u5834\u3067\u30c7\u30fc\u30bf\u3092\u5171\u6709\u3067\u304d\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u30dd\u30fc\u30c8\u30d5\u30a9\u30ea\u30aa\u306e2\u3064\u76ee\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u306f\u3001\u7d30\u80de\uff0b\u30c7\u30d0\u30a4\u30b9\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u3059\u3002\u3053\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u306f\u3001IND\u304c\u4eca\u5e74\u5f8c\u534a\u306b\u4e88\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30c7\u30fc\u30bf\u958b\u793a\u306e\u9762\u3067\u4f55\u3092\u671f\u5f85\u3059\u3079\u304d\u304b\u3001\u3044\u3064\u30c7\u30fc\u30bf\u3092\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u304c\u3001\u79c1\u306f1\u578b\u7cd6\u5c3f\u75c5\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3064\u3044\u3066\u3001\u7d30\u80de\u5358\u72ec\u304b\u7d30\u80de\uff0b\u30c7\u30d0\u30a4\u30b9\u304b\u306b\u304b\u304b\u308f\u3089\u305a\u3001CTX001\u306b\u8fd1\u304f\u3001\u4f4e\u5206\u5b50\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u306f\u3042\u307e\u308a\u4f3c\u3066\u3044\u306a\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u3064\u307e\u308a\u30011\u56de\u3067\u6cbb\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u6cbb\u7642\u3092\u60a3\u8005\u3055\u3093\u306b\u884c\u3046\u306e\u3067\u3001\u60a3\u8005\u3055\u3093\u306e\u6570\u304c\u5c11\u306a\u304f\u3066\u3082\u3001\u6cbb\u7642\u52b9\u679c\u3084\u65b0\u3057\u3044\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u3064\u3044\u3066\u591a\u304f\u306e\u3053\u3068\u3092\u77e5\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u3067\u3059\u304b\u3089\u3001\u3044\u3064\u30c7\u30fc\u30bf\u304c\u51fa\u308b\u304b\u306b\u3064\u3044\u3066\u6b63\u78ba\u306b\u30b3\u30e1\u30f3\u30c8\u3059\u308b\u306b\u306f\u5c11\u3057\u65e9\u3059\u304e\u307e\u3059\u304c\u3001\u3053\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u306f\u4f4e\u5206\u5b50\u5316\u5408\u7269\u3088\u308a\u3082CTX\u306b\u8fd1\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u6700\u5f8c\u306b\u30011\u578b\u7cd6\u5c3f\u75c5\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u307e\u3068\u3081\u308b\u3068\u3001\u3053\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u7b2c3\u306e\u67f1\u306f\u3001\u540c\u3058\u30a8\u30af\u30b5\u30bb\u30eb\u3001\u3064\u307e\u308a\u81e8\u5e8a\u3067\u3059\u3067\u306b\u52b9\u679c\u3092\u5b9f\u8a3c\u3057\u3066\u3044\u308bVX-880\u7d30\u80de\u3067\u3001\u305d\u306e\u7d30\u80de\u3092\u7de8\u96c6\u3057\u3066\u3001\u514d\u75ab\u7cfb\u304b\u3089\u906e\u65ad\u3057\u3001\u514d\u75ab\u6291\u5236\u5264\u3092\u4f7f\u308f\u306a\u304f\u3066\u3082\u3088\u3044\u3088\u3046\u306b\u3059\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n

\u30b9\u30fc\u30b8\u30fc\u30ea\u30b6 — \u6295\u8cc7\u5bb6\u5411\u3051\u5e83\u5831\u62c5\u5f53\u4e0a\u7d1a\u526f\u793e\u9577<\/p>\n

\u6b21\u306e\u8cea\u554f\u3001\u30c1\u30e3\u30c3\u30af\u3055\u3093\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

\u30aa\u30da\u30ec\u30fc\u30bf\u30fc<\/p>\n

\u6b21\u306e\u8cea\u554f\u306f\u3001\u30a6\u30a7\u30eb\u30ba\u30fb\u30d5\u30a1\u30fc\u30b4\u306e\u30e2\u30d2\u30c3\u30c8\u30fb\u30d0\u30f3\u30b5\u30eb\u304b\u3089\u3067\u3059\u3002\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

Mohit Bansal — Wells Fargo Securities — \u30a2\u30ca\u30ea\u30b9\u30c8<\/p>\n

\u7d20\u6674\u3089\u3057\u3044\u3002\u79c1\u306e\u8cea\u554f\u3092\u805e\u3044\u3066\u304f\u3060\u3055\u3063\u3066\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u79c1\u306e\u65b9\u304b\u3089\u3082\u30b9\u30fc\u30b8\u30fc\u30ea\u30b6\u3092\u6b53\u8fce\u3057\u307e\u3059\u3002\u3053\u306e\u5897\u5f37\u5264\u3068\u88dc\u6b63\u5264\u3067\u6700\u5927\u9650\u306e\u52b9\u679c\u3092\u5f15\u304d\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u304b\u3001FEV\u306e\u52b9\u679c\u306b\u3064\u3044\u30661\u3064\u3060\u3051\u8cea\u554f\u3055\u305b\u3066\u304f\u3060\u3055\u3044\u3002\u3042\u308b\u5c02\u9580\u5bb6\u304c\u3001TRIKAFTA\u306e\u6539\u5584\u7387\u304c14\uff05\u3067\u3042\u308c\u3070\u3001\u9ad8\u3044\u65b9\u3067\u3001\u3042\u30683\u30014\uff05\u3067\u3001\u3053\u306e\u7a2e\u306e\u6cbb\u7642\u3067\u9054\u6210\u3067\u304d\u308b\u6700\u5927\u306e\u30d7\u30e9\u30c8\u30fc\u306b\u9054\u3059\u308b\u3060\u308d\u3046\u3068\u8ff0\u3079\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u6b21\u4e16\u4ee3\u30b3\u30f3\u30dc\u304c\u305d\u3053\u306b\u5230\u9054\u3057\u305f\u3068\u4eee\u5b9a\u3057\u3066\u3001\u3053\u306e\u7a2e\u306e\u6cbb\u7642\u3067\u9054\u6210\u3067\u304d\u308b\u6700\u5927\u5024\u306f\u304a\u305d\u3089\u304f\u3053\u308c\u3060\u308d\u3046\u3068\u3044\u3046\u610f\u898b\u306b\u540c\u610f\u3055\u308c\u307e\u3059\u304b\uff1f\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

Reshma Kewalramani — \u6700\u9ad8\u7d4c\u55b6\u8cac\u4efb\u8005\u517c\u793e\u9577<\/p>\n

Mohit\u3055\u3093\u3001\u3069\u3046\u3082\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002\u3054\u8cea\u554f\u306f\u3001CFTR\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u5168\u822c\u306b\u3064\u3044\u3066\u3067\u3057\u3087\u3046\u304b\uff1f\u307e\u305f\u3001\u5229\u76ca\u3068\u3044\u3046\u70b9\u3067\u306f\u4f55\u304c\u671f\u5f85\u3067\u304d\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u305d\u306e\u8cea\u554f\u3092\u3082\u3046\u5c11\u3057\u5439\u304d\u51fa\u3057\u3066\u5e83\u3052\u3066\u307f\u307e\u3059\u3002CFTR\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u306e\u6709\u7528\u6027\u306b\u3064\u3044\u3066\u8003\u3048\u308b\u3068\u304d\u3001CF\u306f\u75c5\u6c17\u3068\u3057\u3066\u3001\u5168\u8eab\u6027\u306e\u75c5\u6c17\u3067\u3042\u308b\u3053\u3068\u3092\u8a8d\u8b58\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n

\u3064\u307e\u308a\u3001\u552f\u4e00\u306e\u75c7\u72b6\u306f\u80ba\u3067\u306f\u306a\u3044\u306e\u3067\u3059\u3002\u80ba\u306f\u975e\u5e38\u306b\u76ee\u7acb\u3064\u75c7\u72b6\u3067\u3059\u304c\u3001\u305d\u308c\u3060\u3051\u304c\u75c7\u72b6\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3067\u306f\u3001\u3069\u3046\u3044\u3046\u3053\u3068\u304b\u3068\u3044\u3046\u3068 CF\u306e\u60a3\u8005\u3055\u3093\u306f\u3001\u809d\u81d3\u75be\u60a3\u306b\u3082\u96e3\u304c\u3042\u308a\u307e\u3059\u3002\u5185\u5206\u6ccc\u3084\u5916\u5206\u6ccc\u306e\u81b5\u81d3\u75be\u60a3\u306b\u3082\u96e3\u304c\u3042\u308a\u307e\u3059\u3057\u3001CFTR\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u304c\u306a\u3044\u5834\u5408\u3001\u4f53\u91cd\u3084\u8eab\u9577\u3092\u5897\u3084\u3057\u3001\u8cea\u306e\u9ad8\u3044\u751f\u6d3b\u3092\u9001\u308b\u3053\u3068\u304c\u96e3\u3057\u3044\u3053\u3068\u306f\u3054\u5b58\u77e5\u306e\u901a\u308a\u3067\u3059\u3002<\/p>\n

CFTR\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u306e\u672c\u5f53\u306e\u5229\u70b9\u306f\u3001\u30ab\u30ea\u30fc\u30c7\u30b3\u304b\u3089\u59cb\u307e\u308a\u3001\u30c8\u30ea\u30ab\u30d5\u30bf\u306b\u81f3\u308b\u307e\u3067\u3001\u80ba\u6a5f\u80fd\u306e\u6539\u5584\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u305d\u308c\u3092\u6e2c\u5b9a\u3059\u308b\u306e\u304cppFEV1\u3067\u3059\u3002TRIKAFTA\u3067\u9054\u6210\u3057\u305f14%\u306f\u6700\u5927\u5024\u306a\u306e\u3067\u3057\u3087\u3046\u304b\u3002ppFEV1\u306e\u52b9\u679c\u304c\u6700\u5927\u306b\u306a\u308b\u304b\u3069\u3046\u304b\u306f\u3001\u307e\u3060\u5224\u65ad\u304c\u3064\u304b\u306a\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u6b21\u306e\u30a4\u30f3\u30af\u30e9\u30b9\u306e\u7d44\u307f\u5408\u308f\u305b\u306f\u3001VX-121\u3001\u30c6\u30b6\u30ab\u30d5\u30c8\u30fc\u30eb\u3001561\u306e\u7d44\u307f\u5408\u308f\u305b\u3067\u3059\u3002<\/p>\n

\u7b2c2\u76f8\u8a66\u9a13\u3067\u306f\u3001\u6700\u5927\u306720\uff05\u306e\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u96c6\u56e3\u304c\u691c\u7d22\u3055\u308c\u307e\u3057\u305f\u3002\u3067\u3059\u304b\u3089\u3001\u5be9\u67fb\u306f\u307e\u3060\u7d42\u308f\u3063\u3066\u3044\u306a\u3044\u3068\u601d\u3044\u307e\u3059\u3057\u3001\u6b21\u306e\u5206\u5b50\u306b\u3082\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002NACFC\u3067\u306f\u3001TRIKAFTA\u3084\u305d\u306e\u4ed6\u306eCFTR\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u306e\u30c7\u30fc\u30bf\u3092\u542b\u3080\u3044\u304f\u3064\u304b\u306e\u6f14\u984c\u304c\u767a\u8868\u3055\u308c\u307e\u3059\u3002ppFEV1\u306b\u5bfe\u3059\u308b\u52b9\u679c\u304c\u3001\u6b7b\u4ea1\u7387\u3001\u80ba\u79fb\u690d\u3001\u5165\u9662\u3001\u80ba\u5897\u60aa\u306e\u9762\u3067\u3082\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u3001\u672c\u5f53\u306b\u5fc3\u5f37\u304f\u601d\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u30b9\u30fc\u30b8\u30fc \u30ea\u30b5 — \u6295\u8cc7\u5bb6\u5411\u3051\u5e83\u5831\u62c5\u5f53\u4e0a\u7d1a\u526f\u793e\u9577<\/p>\n

\u6b21\u306e\u8cea\u554f\u3001\u30c1\u30e3\u30c3\u30af\u3055\u3093\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

\u30aa\u30da\u30ec\u30fc\u30bf\u30fc<\/p>\n

\u6b21\u306e\u8cea\u554f\u306f\u3001\u30b4\u30fc\u30eb\u30c9\u30de\u30f3\u30fb\u30b5\u30c3\u30af\u30b9\u306e\u30b5\u30eb\u30f4\u30a3\u30fc\u30f3\u30fb\u30ea\u30af\u30bf\u30fc\u304b\u3089\u3067\u3059\u3002\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

\u30b5\u30eb\u30f4\u30a3\u30fc\u30f3\u30fb\u30ea\u30d2\u30bf\u30fc — \u30b4\u30fc\u30eb\u30c9\u30de\u30f3\u30fb\u30b5\u30c3\u30af\u30b9 — \u30a2\u30ca\u30ea\u30b9\u30c8<\/p>\n

\u3053\u3093\u306b\u3061\u306f\u3002\u79c1\u306e\u8cea\u554f\u306b\u7b54\u3048\u3066\u304f\u308c\u3066\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002\u79c1\u304b\u3089\u306f2\u3064\u3060\u3051\u3067\u3059\u30021\u3064\u306f\u30011\u578b\u7cd6\u5c3f\u75c5\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3064\u3044\u3066\u3067\u3059\u3002<\/p>\n

\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304b\u3089\u7d30\u80de\u3092\u5b8c\u5168\u306b\u4fdd\u8b77\u3059\u308b\u3068\u540c\u6642\u306b\u3001\u30c7\u30d0\u30a4\u30b9\u306e\u4e2d\u3067\u7d30\u80de\u306e\u5b8c\u5168\u6027\u3092\u7dad\u6301\u3059\u308b\u65b9\u6cd5\u306b\u3064\u3044\u3066\u6559\u3048\u3066\u304f\u3060\u3055\u3044\u3002\u6b21\u306b\u3001100\u5104\u30c9\u30eb\u306e\u73fe\u91d1\u3092\u304a\u6301\u3061\u3067\u3059\u306d\u3002\u3082\u3057\u3001\u4fa1\u5024\u3092\u5275\u9020\u3059\u308b\u3088\u3046\u306a\u4e8b\u696d\u958b\u767a\u3092\u884c\u308f\u306a\u3044\u306e\u3067\u3042\u308c\u3070\u3001\u81ea\u793e\u682a\u8cb7\u3044\u3084\u914d\u5f53\u91d1\u3067\u9084\u5143\u3059\u308b\u3053\u3068\u3092\u671f\u5f85\u3059\u3079\u304d\u3067\u3057\u3087\u3046\u304b\u3002\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u30ec\u30b9\u30de\u30fb\u30b1\u30ef\u30e9\u30de\u30cb\uff08Reshma Kewalramani\uff09 — \u6700\u9ad8\u7d4c\u55b6\u8cac\u4efb\u8005\u517c\u793e\u9577<\/p>\n

\u30b5\u30eb\u30f4\u30a3\u30fc\u30f3\u3001\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002\u307e\u305a1\u578b\u7cd6\u5c3f\u75c5\u306b\u3064\u3044\u3066\u3001\u305d\u3057\u3066\u8cc7\u672c\u914d\u5206\u306e\u8cea\u554f\u3067\u3059\u304c\u3001\u8a73\u7d30\u306f\u30c1\u30e3\u30fc\u30ea\u30fc\u306b\u304a\u9858\u3044\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u30021\u578b\u7cd6\u5c3f\u75c5\u30d7\u30ed\u30b0\u30e9\u30e0\u304a\u3088\u3073\u7d30\u80de\uff0b\u30c7\u30d0\u30a4\u30b9\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3064\u3044\u3066\u306f\u3001\u79c1\u305f\u3061\u306f\u9577\u3044\u9593\u61f8\u547d\u306b\u53d6\u308a\u7d44\u3093\u3067\u304d\u307e\u3057\u305f\u3057\u3001\u8cb7\u53ce\u4ee5\u524d\u304b\u3089\u3053\u308c\u306b\u53d6\u308a\u7d44\u3093\u3067\u304d\u305f\u30bb\u30f3\u30de\u306e\u30c1\u30fc\u30e0\u306b\u3082\u611f\u8b1d\u3057\u3066\u3044\u307e\u3059\u30021\u3064\u306f\u3001\u7d30\u80de\u306b\u5341\u5206\u306a\u9178\u7d20\u3068\u6804\u990a\u3092\u4e0e\u3048\u308b\u3053\u3068\u30012\u3064\u306f\u3001\u7570\u7269\u53cd\u5fdc\u3092\u9632\u3050\u3053\u3068\u30013\u3064\u306f\u3001\u6804\u990a\u3068\u9178\u7d20\u306f\u5165\u308b\u304c\u514d\u75ab\u7d30\u80de\u306f\u5165\u3089\u306a\u3044\u3088\u3046\u306b\u7d30\u80de\u3092\u4fdd\u8b77\u3057\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u611f\u77e5\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u653e\u51fa\u304c\u78ba\u5b9f\u306b\u884c\u308f\u308c\u308b\u3088\u3046\u306b\u3059\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n

VX-880\u3067\u4f7f\u7528\u3059\u308b\u72ec\u81ea\u306e\u30c7\u30d0\u30a4\u30b9\u306f\u3001\u7d30\u80de\u3092\u4fdd\u8b77\u3057\u3064\u3064\u3001\u6804\u990a\u3068\u9178\u7d20\u306e\u6d41\u308c\u3092\u78ba\u4fdd\u3059\u308b\u3068\u3044\u3046\u3001\u3053\u308c\u3089\u306e\u554f\u984c\u3092\u8003\u616e\u3057\u3001\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306e\u6a5f\u80fd\u3092\u5099\u3048\u3066\u3044\u307e\u3059\u30022\u3064\u76ee\u306f\u3001\u5927\u52d5\u7269\u5b9f\u9a13\u3082\u542b\u3081\u305f\u3059\u3079\u3066\u306e\u524d\u81e8\u5e8a\u8a66\u9a13\u3067\u3001\u7570\u7269\u53cd\u5fdc\u304c\u898b\u3089\u308c\u306a\u3044\u3053\u3068\u3067\u3059\u3002\u305d\u3057\u30663\u3064\u76ee\u306f\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u3092\u611f\u77e5\u3057\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u3092\u653e\u51fa\u3059\u308b\u80fd\u529b\u3092\u6301\u3064\u3053\u3068\u3067\u3059\u3002\u30b5\u30eb\u30f4\u30a3\u30fc\u30f3\u30011\u578b\u7cd6\u5c3f\u75c5\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u6700\u3082\u56f0\u96e3\u306a\u90e8\u5206\u306f\u3001\u5b9f\u969b\u306b\u5b8c\u5168\u306b\u5206\u5316\u3057\u305f\u30a4\u30f3\u30b9\u30ea\u30f3\u7523\u751f\u7d30\u80de\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u3060\u3001\u3068\u7533\u3057\u4e0a\u3052\u3066\u304a\u304d\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u90e8\u5206\u306b\u3064\u3044\u3066\u306f\u3001\u534a\u91cf\u3067\u6cbb\u7642\u3057\u305f\u6700\u521d\u306e2\u4eba\u306e\u60a3\u8005\u3055\u3093\u3067\u6982\u5ff5\u5b9f\u8a3c\u304c\u9054\u6210\u3055\u308c\u305f\u306e\u3067\u3001\u3082\u3046\u5927\u4e08\u592b\u3060\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u8cc7\u672c\u914d\u5206\u306e\u8cea\u554f\u3067\u3059\u304c\u3001\u8cc7\u672c\u306b\u95a2\u3059\u308b\u79c1\u305f\u3061\u306e\u6226\u7565\u306f\u5909\u308f\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u7126\u70b9\u306f\u3001\u793e\u5185\u5916\u306e\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u306b\u3042\u308a\u307e\u3059\u3002\u30c1\u30e3\u30fc\u30ea\u30fc\u3001\u4f55\u304b\u88dc\u8db3\u3059\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u3059\u304b\uff1f<\/p>\n

\u30c1\u30e3\u30fc\u30ea\u30fc\u30fb\u30ef\u30b0\u30ca\u30fc — \u6700\u9ad8\u8ca1\u52d9\u8cac\u4efb\u8005<\/p>\n

\u3044\u3044\u3048\u3001\u3068\u3066\u3082\u3088\u304f\u304a\u3063\u3057\u3083\u3044\u307e\u3057\u305f\u3002\u512a\u5148\u9806\u4f4d\u306f\u5f15\u304d\u7d9a\u304d\u3001\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u3078\u306e\u6295\u8cc7\u3067\u3059\u3002\u3053\u3053\u6570\u5e74\u3001\u79c1\u305f\u3061\u306f\u975e\u5e38\u306b\u7a4d\u6975\u7684\u306b\u53d6\u308a\u7d44\u3093\u3067\u304d\u3066\u304a\u308a\u3001\u305d\u308c\u304c\u8868\u308c\u3066\u3044\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u73fe\u5728\u306e\u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u3092\u898b\u308b\u3068\u300140%\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u3053\u3053\u6570\u5e74\u306eBD\u304b\u3089\u6069\u6075\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u79c1\u305f\u3061\u306f\u7a4d\u6975\u7684\u306a\u6a5f\u80fd\u3092\u7dad\u6301\u3057\u3001\u793e\u5185\u306e\u53d6\u308a\u7d44\u307f\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u305f\u3081\u306b\u5916\u90e8\u306e\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u306b\u76ee\u3092\u5411\u3051\u3001\u4eca\u5f8c\u3082\u512a\u5148\u9806\u4f4d\u3092\u9ad8\u3081\u3066\u3044\u304f\u3064\u3082\u308a\u3067\u3059\u3002\u307e\u305f\u3001\u8fd1\u5e74\u306f\u5e0c\u8584\u5316\u3092\u88dc\u3046\u305f\u3081\u306b\u81ea\u793e\u682a\u8cb7\u3044\u3092\u7d9a\u3051\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u76ee\u7684\u306f\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u3078\u306e\u6295\u8cc7\u3067\u3059\u3002<\/p>\n

Salveen Richter — \u30b4\u30fc\u30eb\u30c9\u30de\u30f3\u30fb\u30b5\u30c3\u30af\u30b9 — \u30a2\u30ca\u30ea\u30b9\u30c8<\/p>\n

\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u30b9\u30fc\u30b8\u30fc\u30ea\u30b6 — \u30a4\u30f3\u30d9\u30b9\u30bf\u30fc\u30ea\u30ec\u30fc\u30b7\u30e7\u30f3\u30ba\u62c5\u5f53\u4e0a\u7d1a\u526f\u793e\u9577<\/p>\n

\u30b5\u30eb\u30f4\u30a3\u30fc\u30f3\u3055\u3093\u3001\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002\u6b21\u306e\u8cea\u554f\u306f\u3001\u30c1\u30e3\u30c3\u30af\u3055\u3093\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

\u30aa\u30da\u30ec\u30fc\u30bf\u30fc<\/p>\n

\u6b21\u306e\u8cea\u554f\u306f\u30b3\u30fc\u30a6\u30a7\u30f3\u30a2\u30f3\u30c9\u30ab\u30f3\u30d1\u30cb\u30fc\u306e\u30d5\u30a3\u30eb\u30fb\u30ca\u30c9\u30fc\u304b\u3089\u3067\u3059\u3002\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

\u30d5\u30a3\u30eb\u30fb\u30ca\u30c9\u30fc — \u30b3\u30fc\u30a6\u30a7\u30f3\u30fb\u30a2\u30f3\u30c9\u30fb\u30ab\u30f3\u30d1\u30cb\u30fc — \u30a2\u30ca\u30ea\u30b9\u30c8<\/p>\n

\u3053\u3093\u306b\u3061\u306f\u3002\u8cea\u554f\u3092\u304a\u53d7\u3051\u3044\u305f\u3060\u304d\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002\u30a4\u30ca\u30af\u30b5\u30d7\u30ea\u30f3\u306e\u7b2c2\/3\u76f8\u8a66\u9a13\u306b\u3064\u3044\u3066\u3001\u7279\u306b\u7b2c2\/3\u76f8\u306e\u90e8\u5206\u306b\u3064\u3044\u3066\u304a\u805e\u304d\u3057\u305f\u3044\u306e\u3067\u3059\u304c\u3002\u305d\u306e\u7b2c2\u76f8\u90e8\u5206\u306e\u30c7\u30fc\u30bf\u304c\u958b\u793a\u3055\u308c\u308b\u304b\u3069\u3046\u304b\u306b\u3064\u3044\u3066\u3001\u30d0\u30fc\u30c6\u30c3\u30af\u30b9\u306e\u6700\u65b0\u306e\u8003\u3048\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u304b\u3002\u307e\u305f\u3001\u3088\u308a\u4e00\u822c\u7684\u306a\u3053\u3068\u3067\u3059\u304c\u3001\u7b2c3\u76f8\u8a66\u9a13\u306b\u9032\u3081\u308b\u7528\u91cf\u3092\u3069\u306e\u3088\u3046\u306a\u57fa\u6e96\u3067\u9078\u629e\u3059\u308b\u306e\u304b\u3001\u6559\u3048\u3066\u304f\u3060\u3055\u3044\u3002\u305d\u306e\u5224\u65ad\u306e\u305f\u3081\u306b\u3001\u3069\u306e\u3088\u3046\u306a\u6307\u6a19\u3092\u691c\u8a0e\u3055\u308c\u308b\u306e\u3067\u3057\u3087\u3046\u304b\u3002<\/p>\n

Reshma Kewalramani — \u6700\u9ad8\u7d4c\u55b6\u8cac\u4efb\u8005\u517c\u793e\u9577<\/p>\n

\u30d5\u30a3\u30eb\u3001\u30a4\u30ca\u30af\u30b5\u30d7\u30ea\u30f3\u306e\u8a66\u9a13\u3001\u3064\u307e\u308aAMKD\uff08APOL1\u4ecb\u5728\u6027\u814e\u75be\u60a3\uff09\u3092\u5bfe\u8c61\u3068\u3057\u305fVX-147\u8a66\u9a13\u306f\u3001\u9069\u5fdc\u3068\u306a\u308b\u7b2c2\/3\u76f8\u8a66\u9a13\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u3059\u3002\u6295\u4e0e\u91cf\u9078\u629e\u306e\u57fa\u6e96\u306f\u300112\u9031\u6642\u70b9\u306e\u6709\u52b9\u6027\u3092\u4e2d\u5fc3\u306b\u8a2d\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u57fa\u6e96\u306f\u3001\u30bf\u30f3\u30d1\u30af\u5c3f\u3067\u3059\u3002<\/p>\n

\u30bf\u30f3\u30d1\u30af\u5c3f\u306f\u300112\u9031\u9593\u306e\u9593\u306b\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002GFR\u306e\u5909\u5316\u306b\u3064\u3044\u3066\u306f\u3001\u305d\u3046\u306f\u3044\u304d\u307e\u305b\u3093\u3002\u59d4\u54e1\u4f1a\u304c\u30c7\u30fc\u30bf\u3092\u898b\u3066\u5224\u65ad\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3059\u3057\u3001\u8a66\u9a13\u306e\u5b8c\u5168\u6027\u3092\u7dad\u6301\u3059\u308b\u5fc5\u8981\u6027\u304b\u3089\u3001\u9069\u5207\u306a\u65b9\u6cd5\u3067\u5224\u65ad\u3055\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u7b2c2\u76f8\u3068\u3044\u3046\u91cd\u8981\u306a\u30de\u30a4\u30eb\u30b9\u30c8\u30fc\u30f3\u3092\u4e57\u308a\u8d8a\u3048\u3001\u6295\u4e0e\u91cf\u304c\u6c7a\u5b9a\u3055\u308c\u305f\u3068\u3044\u3046\u4e8b\u5b9f\u306f\u3001\u79c1\u305f\u3061\u3082\u5171\u6709\u3059\u308b\u3053\u3068\u306b\u306a\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u3057\u304b\u3057\u3001\u81e8\u5e8a\u8a66\u9a13\u306b\u53c2\u52a0\u3057\u3066\u3044\u308b\u60a3\u8005\u3055\u3093\u304c\u3044\u3066\u3001\u7b2c3\u76f8\u306e\u90e8\u5206\u307e\u3067\u7d99\u7d9a\u3059\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001\u5b89\u5b9a\u3057\u305f\u6574\u5408\u6027\u3092\u7dad\u6301\u3059\u308b\u3053\u3068\u306b\u6ce8\u610f\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n

Phil Nadeau — \u30b3\u30fc\u30a6\u30a7\u30f3\u30a2\u30f3\u30c9\u30ab\u30f3\u30d1\u30cb\u30fc — \u30a2\u30ca\u30ea\u30b9\u30c8<\/p>\n

\u305d\u308c\u306f\u52a9\u304b\u308a\u307e\u3059\u3002\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002<\/p>\n

\u30aa\u30da\u30ec\u30fc\u30bf\u30fc<\/p>\n

\u6b21\u306e\u8cea\u554f\u306f\u3001BMO\u306eEvan Seigerman\u304b\u3089\u3067\u3059\u3002\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

\u30a8\u30f4\u30a1\u30f3\u30fb\u30bb\u30a4\u30ac\u30fc\u30de\u30f3 — BMO\u30ad\u30e3\u30d4\u30bf\u30eb\u30de\u30fc\u30b1\u30c3\u30c4 — \u30a2\u30ca\u30ea\u30b9\u30c8<\/p>\n

\u3069\u3046\u3082\u3001\u7686\u3055\u3093\u3002\u79c1\u306e\u8cea\u554f\u3092\u805e\u3044\u3066\u304f\u3060\u3055\u3063\u3066\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u597d\u8abf\u306a\u56db\u534a\u671f\u306b\u3064\u3044\u3066\u672c\u5f53\u306b\u304a\u3081\u3067\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002864\u306b\u3064\u3044\u3066\u3001\u3053\u306e\u8cc7\u7523\u3067\u81e8\u5e8a\u8a66\u9a13\u3092\u518d\u958b\u3059\u308b\u305f\u3081\u306b\u898b\u305f\u3053\u3068\u306b\u3064\u3044\u3066\u3001\u3082\u3046\u5c11\u3057\u8a73\u3057\u304f\u6559\u3048\u3066\u3044\u305f\u3060\u3051\u308b\u3068\u5e78\u3044\u3067\u3059\u3002\u307e\u305f\u3001634\u756a\u304c\u524d\u4efb\u8005\u3088\u308a\u3082\u6210\u529f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u7406\u7531\u3082\u6559\u3048\u3066\u304f\u3060\u3055\u3044\u3002\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u30ec\u30b7\u30e5\u30de\u30fb\u30b1\u30ef\u30e9\u30de\u30cb — \u6700\u9ad8\u7d4c\u55b6\u8cac\u4efb\u8005\u517c\u793e\u9577<\/p>\n

\u3084\u3042\u3001\u30a8\u30d0\u30f3\u3002\u3053\u3093\u306b\u3061\u306f\u3002\u30a2\u30eb\u30d5\u30a11\u30a2\u30f3\u30c1\u30c8\u30ea\u30d7\u30b7\u30f3\u6b20\u640d\u75c7\uff08AATD\uff09\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3064\u3044\u3066\u306e\u3054\u8cea\u554f\u3067\u3059\u306d\u3002<\/p>\n

\u306a\u305c\u79c1\u305f\u3061\u304c\u3053\u306e\u75c5\u6c17\u306b\u95a2\u5fc3\u3092\u6301\u3064\u306e\u304b\u3001\u534a\u6b69\u4e0b\u304c\u3063\u3066\u7686\u3055\u3093\u306b\u8aac\u660e\u3055\u305b\u3066\u304f\u3060\u3055\u3044\u3002AATD\u306f\u3001VERTEX\u306e\u6226\u7565\u3001\u3064\u307e\u308a\u79c1\u305f\u3061\u306e\u7814\u7a76\u958b\u767a\u6226\u7565\u306b\u3074\u3063\u305f\u308a\u306a\u306e\u3067\u3059\u3002\u3053\u306e\u75c5\u6c17\u306f\u3001\u539f\u56e0\u3068\u306a\u308b\u30d2\u30c8\u306e\u751f\u7269\u5b66\u7684\u6027\u8cea\u304c\u308f\u304b\u3063\u3066\u3044\u308b\u75c5\u6c17\u3067\u3059\u3002\u6709\u52b9\u306a\u30bf\u30fc\u30b2\u30c3\u30c8\u304c\u3042\u308a\u3001\u30d9\u30f3\u30c1\u304b\u3089\u30d9\u30c3\u30c9\u30b5\u30a4\u30c9\u306b\u79fb\u884c\u3067\u304d\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u75c5\u6c17\u306f\u3001\u6b27\u7c73\u3067\u7d0410\u4e07\u4eba\u304c\u7f79\u60a3\u3057\u3066\u3044\u307e\u3059\u3002\u3068\u3053\u308d\u3067\u3001\u3053\u306e\u75c5\u6c17\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306e\u75c5\u6c17\u3067\u3042\u308a\u3001\u56a2\u80de\u6027\u7dda\u7dad\u75c7\u306e\u7814\u7a76\u304b\u3089\u79c1\u305f\u3061\u304c\u5c11\u3057\u77e5\u3063\u3066\u3044\u308b\u80ba\u306e\u75c5\u6c17\u3067\u3082\u3042\u308a\u307e\u3059\u3002\u3067\u3059\u304b\u3089\u3001\u3053\u306e\u75c5\u6c17\u306f\u79c1\u305f\u3061\u306b\u3074\u3063\u305f\u308a\u306a\u306e\u3067\u3059\u3002<\/p>\n

VX-864\u306e\u7b2c2\u76f8\u8a66\u9a13\u3067\u308f\u304b\u3063\u305f\u3053\u3068\u306f\u3001864\u306f\u7b2c\u4e00\u4e16\u4ee3\u306eAAT\u88dc\u6b63\u85ac\u3067\u3059\u304c\u3001\u4f4e\u5206\u5b50\u5316\u5408\u7269\u304c\u521d\u3081\u3066AAT\u306e\u6a5f\u80fd\u30ec\u30d9\u30eb\u3092\u4e0a\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u3053\u308c\u306f\u3001\u3053\u308c\u307e\u3067\u5b9f\u8a3c\u3055\u308c\u305f\u3053\u3068\u306e\u306a\u3044\u3053\u3068\u3067\u3059\u3002\u307e\u305f\u3001\u63a2\u7d22\u7684\u89e3\u6790\u3067\u306f\u3001\u8840\u6e05\u30dd\u30ea\u30de\u30fc\u30ec\u30d9\u30eb\u309290%\u4ee5\u4e0a\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u3092\u7dcf\u5408\u3057\u3066\u3001\u79c1\u305f\u3061\u306f\u4eca\u3001\u3053\u306e\u3088\u3046\u306a\u72b6\u6cc1\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u3053\u306e2\u3064\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u4e26\u884c\u3057\u3066\u884c\u3063\u3066\u3044\u308b\u306e\u304c\u3001864\u3088\u308a\u3082\u5f37\u529b\u306a\u533b\u85ac\u54c1\u3092\u4e16\u306b\u9001\u308a\u51fa\u3059\u3068\u3044\u3046\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3059\u3002\u305d\u308c\u304cVX-634\u3067\u3059\u3002VX-634\u306f\u4f55\u500d\u3082\u5f37\u529b\u3067\u3059\u3002\u3088\u308a\u512a\u308c\u305f\u85ac\u7269\u69d8\u7279\u6027\u3092\u6301\u3061\u3001\u7b2c1\u76f8\u8a66\u9a13\u3092\u958b\u59cb\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u305d\u308c\u3068\u4e26\u884c\u3057\u3066\u3001VX-864\u3082\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u5206\u5b50\u306f\u3001\u3088\u308a\u9577\u671f\u7684\u306a\u7814\u7a76\u3092\u884c\u3046\u305f\u3081\u306e\u6162\u6027\u6bd2\u6027\u4fdd\u967a\u304c\u9069\u7528\u3055\u308c\u308b\u304b\u3089\u3067\u3059\u3002\u9577\u671f\u7684\u306a\u7814\u7a76\u3067\u306f\u3001\u30dd\u30ea\u30de\u30fc\u306e\u809d\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u79c1\u305f\u3061\u304c\u898b\u305f\u8840\u6e05\u30dd\u30ea\u30de\u30fc\u306e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u306b\u623b\u308b\u3082\u306e\u3067\u3059\u3002\u3067\u3059\u304b\u3089\u3001\u809d\u81d3\u3067\u306e\u30dd\u30ea\u30de\u30fc\u306e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3068\u3001AAT\u306e\u6a5f\u80fd\u306b\u5bfe\u3059\u308b\u9577\u671f\u7684\u306a\u5f71\u97ff\u3092\u8abf\u3079\u308b\u306e\u3067\u3059\u3002<\/p>\n

\u79c1\u305f\u3061\u306f\u3001\u3053\u306e2\u3064\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u4e26\u884c\u3057\u3066\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u6765\u5e74\u306e\u4eca\u9803\u306b\u306f\u3001\u3069\u306e\u5206\u5b50\u3092\u3055\u3089\u306b\u9032\u3081\u308b\u3079\u304d\u304b\u3092\u8a55\u4fa1\u3059\u308b\u306e\u306b\u5fc5\u8981\u306a\u30c7\u30fc\u30bf\u304c\u5f97\u3089\u308c\u308b\u3068\u601d\u3044\u307e\u3059\u3002\u3053\u308c\u304c\u3001AATD\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u95a2\u3059\u308b\u79c1\u305f\u3061\u306e\u73fe\u72b6\u3067\u3059\u3002<\/p>\n

\u30b9\u30fc\u30b8\u30fc\u30ea\u30b6 — \u6295\u8cc7\u5bb6\u5411\u3051\u5e83\u5831\u62c5\u5f53\u4e0a\u7d1a\u526f\u793e\u9577<\/p>\n

\u6b21\u3092\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

\u30aa\u30da\u30ec\u30fc\u30bf\u30fc<\/p>\n

\u6b21\u306e\u8cea\u554f\u306f\u3001SVB\u8a3c\u5238\u306e\u30c7\u30fc\u30d3\u30c3\u30c9\u30fb\u30ea\u30b8\u30f3\u30ac\u30fc\u304b\u3089\u3067\u3059\u3002\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

\u30c7\u30fc\u30d3\u30c3\u30c9\u30fb\u30e9\u30a4\u30b8\u30f3\u30ac\u30fc — SVB\u30bb\u30ad\u30e5\u30ea\u30c6\u30a3\u30fc\u30ba LLC — \u30a2\u30ca\u30ea\u30b9\u30c8<\/p>\n

\u3069\u3046\u3082\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002\u7279\u306b\u4eca\u65e5\u306e\u5e02\u5834\u306e\u61b6\u6e2c\u3092\u8003\u3048\u308b\u3068\u3001\u3053\u306e\u7d50\u679c\u306b\u3082\u304a\u3081\u3067\u3068\u3046\u3068\u8a00\u308f\u305b\u3066\u304f\u3060\u3055\u3044\u3002VX-548\u306b\u3064\u3044\u3066\u8cea\u554f\u306a\u306e\u3067\u3059\u304c\u3001\u60a3\u8005\u304c\u30aa\u30d4\u30aa\u30a4\u30c9\u3092\u9577\u671f\u6295\u4e0e\u3067\u304d\u306a\u3044\u305f\u3081\u3001\u6162\u6027\u75bc\u75db\u306b\u304a\u3051\u308b\u3053\u306e\u88fd\u54c1\u306e\u6a5f\u4f1a\u306f\u660e\u3089\u304b\u306b\u975e\u5e38\u306b\u5927\u304d\u3044\u3068\u79c1\u306f\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u57fa\u672c\u7684\u306b\u306f\u30011\u9031\u9593\u4ee5\u5185\u306e\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u51e6\u65b9\u3067\u3042\u308c\u3070\u3001\u3082\u3061\u308d\u3093\u65e2\u5b58\u306e\u4e2d\u6bd2\u306e\u554f\u984c\u304c\u306a\u3044\u9650\u308a\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u4e2d\u6bd2\u306e\u30ea\u30b9\u30af\u304c\u306a\u3044\u3068\u601d\u308f\u308c\u308b\u60a3\u8005\u3055\u3093\u306b\u3064\u3044\u3066\u3001\u75c5\u9662\u304c\u5b89\u4fa1\u306a\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u533b\u85ac\u54c1\u306b\u7f6e\u304d\u63db\u3048\u308b\u304b\u3069\u3046\u304b\u3068\u3044\u3046\u3053\u3068\u3067\u3057\u3087\u3046\u304b\u3002\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

Reshma Kewalramani — \u6700\u9ad8\u7d4c\u55b6\u8cac\u4efb\u8005\u517c\u793e\u9577<\/p>\n

\u30c7\u30a4\u30d3\u30c3\u30c9\u3001\u6025\u6027\u75db\u306b\u95a2\u3059\u308b\u8cea\u554f\u306f\u30b9\u30c1\u30e5\u30a2\u30fc\u30c8\u306b\u304a\u9858\u3044\u3057\u3066\u3001\u79c1\u306f\u623b\u3063\u3066\u6162\u6027\u75db\u306b\u3064\u3044\u3066\u4e00\u8a00\u3060\u3051\u3002\u30b9\u30c1\u30e5\u30a2\u30fc\u30c8\uff1f<\/p>\n

\u30b9\u30c1\u30e5\u30a2\u30fc\u30c8\u30fb\u30a2\u30fc\u30d0\u30c3\u30af\u30eb — \u6700\u9ad8\u57f7\u884c\u8cac\u4efb\u8005<\/p>\n

\u3054\u8cea\u554f\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002\u306f\u3044\u3002\u6025\u6027\u75db\u306e\u5e02\u5834\u306b\u3064\u3044\u3066\u3067\u3059\u304c\u3001\u6e96\u5099\u66f8\u9762\u3067\u3082\u7533\u3057\u4e0a\u3052\u305f\u3088\u3046\u306b\u3001\u3044\u304f\u3064\u304b\u306e\u7406\u7531\u304b\u3089\u975e\u5e38\u306b\u5927\u304d\u306a\u30c1\u30e3\u30f3\u30b9\u3060\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u5e74\u959315\u5104\u65e5\u306e\u6cbb\u7642\u65e5\u6570\u304c\u3042\u308a\u3001\u305d\u306e\u591a\u304f\u304c\u75c5\u9662\u5185\u306b\u96c6\u4e2d\u3057\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u300190%\u4ee5\u4e0a\u304c\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u533b\u85ac\u54c1\u3067\u3042\u308b\u3068\u3044\u3046\u4e8b\u5b9f\u3092\u7533\u3057\u4e0a\u3052\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u5e02\u5834\u898f\u6a21\u306f\u73fe\u572840\u5104\u30c9\u30eb\u3067\u3059\u3002\u3064\u307e\u308a\u3001\u672c\u5f53\u306e\u554f\u984c\u306f\u3001\u3053\u3053\u3067\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u30cb\u30fc\u30ba\u306f\u4f55\u304b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u305d\u3057\u3066\u3001\u305d\u306e\u30a2\u30f3\u30e1\u30c3\u30c8\u30fb\u30cb\u30fc\u30ba\u306f\u3001\u5b9f\u306f\u975e\u5e38\u306b\u5927\u304d\u306a\u3082\u306e\u306a\u306e\u3067\u3059\u3002\u3042\u306a\u305f\u306e\u30b3\u30e1\u30f3\u30c8\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u5b9f\u306f\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u6025\u6027\u4f7f\u7528\u306f\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u8513\u5ef6\u306e\u539f\u56e0\u3068\u3057\u3066\u975e\u5e38\u306b\u9855\u8457\u3067\u3042\u308a\u3001\u3088\u304f\u8a8d\u8b58\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u306a\u306e\u3067\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u591a\u304f\u306e\u5dde\u3084\u75c5\u9662\u30b7\u30b9\u30c6\u30e0\u3067\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u4f7f\u7528\u306b\u5927\u304d\u306a\u5236\u7d04\u304c\u8a2d\u3051\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u305d\u306e\u7d50\u679c\u3001\u591a\u304f\u306e\u5dde\u3084\u75c5\u9662\u30b7\u30b9\u30c6\u30e0\u3067\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u4f7f\u7528\u306b\u5927\u304d\u306a\u5236\u7d04\u304c\u8a2d\u3051\u3089\u308c\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u4f7f\u7528\u306f\u5927\u5e45\u306b\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u305d\u308c\u3067\u3082\u306a\u304f\u306a\u3089\u306a\u3044\u306e\u304c\u3001\u60a3\u8005\u3055\u3093\u306e\u4e2d\u7b49\u5ea6\u304b\u3089\u91cd\u5ea6\u306e\u6025\u6027\u75db\u3067\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u306e\u3088\u3046\u306a\u7fd2\u6163\u6027\u3084\u526f\u4f5c\u7528\u304c\u306a\u304f\u3001\u52b9\u679c\u7684\u306b\u75db\u307f\u3092\u7de9\u548c\u3059\u308b\u85ac\u5264\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u5165\u9662\u671f\u9593\uff08\u5e73\u57472\u301c4\u65e5\uff09\u304c\u9577\u3044\u75c5\u9662\u3067\u306f\u3001\u533b\u7642\u4e0a\u306e\u30cb\u30fc\u30ba\u304c\u5341\u5206\u306b\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u305d\u3057\u3066\u5f53\u7136\u306a\u304c\u3089\u3001\u3053\u308c\u3089\u306e\u60a3\u8005\u3055\u3093\u306f\u7d99\u7d9a\u7684\u306a\u75bc\u75db\u7ba1\u7406\u306e\u305f\u3081\u306b\u6570\u65e5\u5206\u306e\u51e6\u65b9\u7b8b\u3092\u6301\u3063\u3066\u9000\u9662\u3057\u3001\u5c0f\u58f2\u5e97\u3067\u305d\u306e\u51e6\u65b9\u7b8b\u3092\u8a18\u5165\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3001VX-548\u306e\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3068\u3001\u6025\u6027\u75db\u306e\u6cbb\u7642\u306b\u5927\u304d\u306a\u5909\u5316\u3092\u3082\u305f\u3089\u3059\u6a5f\u4f1a\u306b\u3001\u79c1\u305f\u3061\u306f\u3068\u3066\u3082\u8208\u596e\u3057\u3066\u3044\u307e\u3059\u3002\u7d9a\u3044\u3066\u3001\u30ec\u30b7\u30e5\u30de\u3055\u3093\u3001\u6162\u6027\u75bc\u75db\u306b\u3064\u3044\u3066\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

Reshma Kewalramani — \u6700\u9ad8\u7d4c\u55b6\u8cac\u4efb\u8005\u517c\u793e\u9577<\/p>\n

\u305d\u3046\u3067\u3059\u306d\u3002David \u79c1\u3082\u3001\u6025\u6027\u75db\u306e\u5927\u304d\u306a\u53ef\u80fd\u6027\u306b\u52a0\u3048\u3066\u3001\u6162\u6027\u75db\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u306f\u540c\u610f\u898b\u3067\u3059\u3002\u6162\u6027\u75bc\u75db\u306b\u30c1\u30e3\u30f3\u30b9\u304c\u3042\u308b\u7406\u7531\u306f\u30012\u3064\u3042\u308a\u307e\u3059\u30021\u3064\u306f\u3001\u3054\u6307\u6458\u306e\u3068\u304a\u308a\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u3092\u6162\u6027\u7684\u306b\u4f7f\u3044\u305f\u304f\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3001\u305d\u3057\u3066\u7387\u76f4\u306b\u8a00\u3063\u3066\u3001\u6025\u6027\u671f\u306b\u3082\u30aa\u30d4\u30aa\u30a4\u30c9\u3092\u4f7f\u3044\u305f\u304f\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n

\u3082\u30461\u3064\u306f\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u306f\u6162\u6027\u7684\u306a\u5834\u9762\u3067\u306e\u6709\u52b9\u6027\u3068\u3044\u3046\u70b9\u3067\u306f\u3001\u5b9f\u306f\u3042\u307e\u308a\u512a\u308c\u3066\u3044\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u4f8b\u3048\u3070\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u306a\u3069\u3067\u306f\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u306f\u975e\u5e38\u306b\u6709\u52b9\u3067\u3059\u3002\u6700\u5f8c\u306b\u3001VX-548\u306e\u7cd6\u5c3f\u75c5\u6027\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7b2c2\u76f8\u7528\u91cf\u8a2d\u5b9a\u8a66\u9a13\u3092\u3001\u4eca\u671f\u4e2d\u306b\u958b\u59cb\u3059\u308b\u4e88\u5b9a\u3067\u3042\u308b\u3053\u3068\u3092\u304a\u77e5\u3089\u305b\u3057\u3066\u304a\u304d\u307e\u3059\u3002\u3053\u306e\u8a66\u9a13\u306b\u3064\u3044\u3066\u306f\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u306e\u907a\u4f1d\u5b50\u7684\u691c\u8a3c\u3060\u3051\u3067\u306a\u304f\u3001\u524d\u8eab\u306e\u5206\u5b50\u3067\u3042\u308bVX-150\u3067\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u306b\u95a2\u3059\u308b\u85ac\u7406\u5b66\u7684\u691c\u8a3c\u3092\u884c\u3063\u305f\u305f\u3081\u3001\u9ad8\u3044\u4fe1\u983c\u6027\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

David Risinger — SVB Securities LLC — \u30a2\u30ca\u30ea\u30b9\u30c8<\/p>\n

\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002<\/p>\n

\u53f8\u4f1a<\/p>\n

\u6b21\u306e\u8cea\u554f\u306f\u3001Truist Securities\u306eRobyn Karnauskas\u304b\u3089\u304a\u9858\u3044\u3057\u307e\u3059\u3002\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

Kripa Devarakonda — Truist Securities — \u30a2\u30ca\u30ea\u30b9\u30c8<\/p>\n

\u3069\u3046\u3082\u3001\u7686\u3055\u3093\u3002\u8cea\u554f\u3092\u304a\u53d7\u3051\u3044\u305f\u3060\u304d\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002\u30ed\u30d3\u30f3\u306b\u4ee3\u308f\u3063\u3066\u30af\u30ea\u30d1\u3067\u3059\u3002AAT\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3064\u3044\u30661\u3064\u3060\u3051\u8cea\u554f\u3055\u305b\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n

\u7b2c1\u76f8\u8a66\u9a13\u304b\u3089\u7b2c2\u76f8\u8a66\u9a13\u306b\u79fb\u884c\u3067\u304d\u308b\u306e\u306f\u3044\u3064\u9803\u3060\u3068\u304a\u8003\u3048\u3067\u3057\u3087\u3046\u304b\uff1f\u307e\u305f\u3001\u5065\u5e38\u8005\u8a66\u9a13\u3092\u884c\u3046\u306b\u306f\u3069\u308c\u304f\u3089\u3044\u306e\u671f\u9593\u304c\u304b\u304b\u308b\u3068\u304a\u8003\u3048\u3067\u3059\u304b\uff1f\u307e\u305f\u3001\u4ee5\u524d\u3001\u6d3b\u6027\u3092\u898b\u308b\u305f\u3081\u306b\u672c\u5f53\u306b\u77ed\u671f\u9593\u306e\u8a66\u9a13\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u3044\u3046\u304a\u8a71\u304c\u3042\u308a\u307e\u3057\u305f\u3002VX-864\u3067\u884c\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001\u305d\u306e\u8003\u3048\u306f\u4f55\u304b\u5909\u308f\u308a\u307e\u3057\u305f\u304b\uff1f\u3082\u30461\u3064\u3001CF\u306emRNA\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3064\u3044\u3066\u8cea\u554f\u3057\u307e\u3059\u3002IND\u306f\u4eca\u5e74\u5f8c\u534a\u306b\u63d0\u51fa\u3055\u308c\u308b\u3068\u306e\u3053\u3068\u3067\u3059\u304c\u3001\u65e9\u3051\u308c\u3070\u3044\u3064\u3054\u308d\u306b\u306a\u308a\u307e\u3059\u304b\uff1f\u81e8\u5e8a\u3078\u306e\u5c0e\u5165\u306f\u3044\u3064\u3054\u308d\u306b\u306a\u308a\u305d\u3046\u3067\u3059\u304b\uff1f\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u3067\u3042\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001IND\u306e\u53d7\u7406\u304c\u9045\u308c\u308b\u3068\u4e88\u60f3\u3055\u308c\u308b\u7406\u7531\u306f\u3042\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

Reshma Kewalramani — \u6700\u9ad8\u7d4c\u55b6\u8cac\u4efb\u8005\u517c\u793e\u9577<\/p>\n

\u306f\u3044\u30012\u3064\u306e\u8cea\u554f\u306b\u5206\u304b\u308c\u3066\u3044\u307e\u3059\u30021\u3064\u306f\u56a2\u80de\u6027\u7dda\u7dad\u75c7\u306emRNA\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3064\u3044\u3066\u3001\u3082\u30461\u3064\u306fAAT\u306b\u3064\u3044\u3066\u3067\u3059\u3002\u307e\u305a\u3001\u56a2\u80de\u6027\u7dda\u7dad\u75c7\u306emRNA\u306b\u3064\u3044\u3066\u3067\u3059\u3002<\/p>\n

\u3064\u307e\u308a\u3001CFTR\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4f5c\u3089\u308c\u305a\u3001CFTR\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u306e\u52b9\u679c\u304c\u5f97\u3089\u308c\u306a\u30445,000\u4eba\u307b\u3069\u306e\u60a3\u8005\u3055\u3093\u306b\u5bfe\u3057\u3066\u3001mRNA\u306e\u5438\u5165\u7642\u6cd5\u3092\u884c\u3046\u3068\u3044\u3046\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3059\u3002IND-enabling\u8a66\u9a13\u306f\u7d42\u4e86\u3057\u3066\u3044\u307e\u3059\u3002IND\u306f\u4eca\u5e74\u4e2d\u306b\u63d0\u51fa\u3055\u308c\u308b\u4e88\u5b9a\u3067\u3059\u3002\u305d\u3057\u3066\u3001\u3042\u306a\u305f\u306e\u8a00\u3046\u3068\u304a\u308a\u3001\u4f4e\u5206\u5b50\u5316\u5408\u7269\u3088\u308a\u3082\u8907\u96d1\u306a\u88fd\u54c1\u3067\u3059\u3002<\/p>\n

\u6838\u9178\u7642\u6cd5\u3084\u7d30\u80de\u7642\u6cd5\u306f\u3053\u30535\u301c8\u5e74\u3001\u4f4e\u5206\u5b50\u306f\u4f55\u5341\u5e74\u3082\u524d\u304b\u3089\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\u3057\u306d\u3002\u3068\u306f\u3044\u3048\u3001CF\u306f\u547d\u3092\u7e2e\u3081\u308b\u975e\u5e38\u306b\u6df1\u523b\u306a\u75c5\u6c17\u3067\u3059\u3002\u305d\u3057\u3066\u3001\u60a3\u8005\u3055\u3093\u306b\u5229\u76ca\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u306e\u3042\u308b\u533b\u85ac\u54c1\u3092\u8fc5\u901f\u306b\u958b\u767a\u3059\u308b\u3053\u3068\u306b\u3001\u3059\u3079\u3066\u306e\u95a2\u4fc2\u8005\u304c\u610f\u6b32\u3092\u71c3\u3084\u3057\u3066\u3044\u308b\u3068\u79c1\u306f\u601d\u3044\u307e\u3059\u3002\u3082\u3061\u308d\u3093\u3001\u4eca\u5f8c\u306e\u96fb\u8a71\u4f1a\u8b70\u3067\u9032\u6357\u72b6\u6cc1\u3092\u3054\u5831\u544a\u3067\u304d\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u3057\u304b\u3057\u3001\u79c1\u306f\u3053\u306e\u9032\u6357\u306b\u975e\u5e38\u306b\u6e80\u8db3\u3057\u3066\u3044\u307e\u3059\u3057\u3001\u4eca\u5e74\u4e2d\u306bIND\u3092\u63d0\u51fa\u3059\u308b\u4e88\u5b9a\u3067\u3042\u308b\u3053\u3068\u3092\u3046\u308c\u3057\u304f\u601d\u3063\u3066\u3044\u307e\u3059\u3002AAT\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u306f\u30012\u3064\u306e\u3053\u3068\u3092\u4e26\u884c\u3057\u3066\u884c\u3063\u3066\u3044\u307e\u3059\u30021\u3064\u306fVX-634\u3092\u30d5\u30a1\u30fc\u30b9\u30c8\u30fb\u30a4\u30f3\u30fb\u30d2\u30e5\u30fc\u30de\u30f3\u8a66\u9a13\u306b\u9032\u3081\u308b\u3053\u3068\u3001\u3082\u30461\u3064\u306fVX-864\u3092\u3088\u308a\u9577\u671f\u9593\u306b\u308f\u305f\u3063\u3066\u7814\u7a76\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u3053\u306e2\u3064\u3092\u4e26\u884c\u3057\u3066\u884c\u3063\u3066\u3044\u308b\u306e\u306f\u3001VX-864\u3092\u9577\u671f\u9593\u306b\u308f\u305f\u3063\u3066\u7814\u7a76\u3059\u308b\u305f\u3081\u306e\u5341\u5206\u306a\u6bd2\u6027\u5b66\u7684\u30ab\u30d0\u30ec\u30c3\u30b8\u304c\u3042\u308b\u304b\u3089\u3067\u3059\u3002\u3053\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u809d\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3092\u8a55\u4fa1\u3059\u308b\u306b\u306f\u3001\u9577\u671f\u9593\u306e\u8a66\u9a13\u304c\u5fc5\u8981\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u3057\u304b\u3057\u3001\u6700\u521d\u306e……\u30d2\u30c8\u3067\u306e\u7814\u7a76\u3068\u3044\u3046\u70b9\u3067\u306f\u3001\u79c1\u305f\u3061\u306e\u5b9f\u7e3e\u3092\u898b\u3066\u3044\u305f\u3060\u3051\u308c\u3070\u308f\u304b\u308a\u307e\u3059\u304c\u3001\u79c1\u305f\u3061\u306f\u826f\u3044\u30da\u30fc\u30b9\u3067\u52d5\u304f\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u6765\u5e74\u306e\u4eca\u9803\u306b\u306f\u3001634\u306e\u30d2\u30c8\u3067\u306e\u6700\u521d\u306e\u7814\u7a76\u306e\u30c7\u30fc\u30bf\u304c\u5f97\u3089\u308c\u3001\u7b2c2\u76f8\u9577\u671f\u7814\u7a76\u306e\u30c7\u30fc\u30bf\u304c\u5f97\u3089\u308c\u308b\u3067\u3057\u3087\u3046\u3002\u305d\u3057\u3066\u3001634\u306b\u7d9a\u304f\u5206\u5b50\u304c\u3055\u3089\u306b\u81e8\u5e8a\u306b\u767b\u5834\u3059\u308b\u3068\u3001\u79c1\u306f\u5927\u3044\u306b\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u3059\u3079\u3066\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u304a\u3044\u3066\u3001\u7279\u306bAAT\u306b\u304a\u3044\u3066\u3001\u79c1\u304c\u671b\u3093\u3067\u3044\u308b\u3088\u3046\u306b\u3001\u9023\u7d9a\u7684\u306a\u30a4\u30ce\u30d9\u30fc\u30b7\u30e7\u30f3\u3068\u30dd\u30fc\u30c8\u30d5\u30a9\u30ea\u30aa\u30fb\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3044\u3046\u6226\u7565\u3092\u5b9f\u884c\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n

Kripa Devarakonda — Truist Securities — \u30a2\u30ca\u30ea\u30b9\u30c8<\/p>\n

\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u53f8\u4f1a<\/p>\n

\u6b21\u306e\u8cea\u554f\u306fJP\u30e2\u30eb\u30ac\u30f3\u306e\u30b8\u30a7\u30b7\u30ab\u30fb\u30d5\u30a1\u30a4\u304b\u3089\u3067\u3059\u3002\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

\u30b8\u30a7\u30b7\u30ab\u30fb\u30d5\u30a1\u30a4 — J.P.\u30e2\u30eb\u30ac\u30f3 — \u30a2\u30ca\u30ea\u30b9\u30c8<\/p>\n

\u3053\u3093\u306b\u3061\u306f\u3002\u79c1\u306e\u8cea\u554f\u306b\u7b54\u3048\u3066\u304f\u308c\u3066\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002\u4eca\u591c\u306f\u3044\u3044\u7d50\u679c\u3067\u3057\u305f\u306d\u3002\u5148\u307b\u3069\u306e\u8cea\u554f\u306e\u7d9a\u304d\u3067\u3059\u3002<\/p>\n

\u5ff5\u306e\u305f\u3081\u304a\u805e\u304d\u3057\u305f\u3044\u306e\u3067\u3059\u304c\u3001864\u306e\u9577\u671f\u30c7\u30fc\u30bf\u3092\u4f5c\u6210\u3057\u3066\u809d\u81d3\u30dd\u30ea\u30de\u30fc\u306e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3092\u8a55\u4fa1\u3057\u3001\u3088\u308a\u512a\u308c\u305f\u85ac\u7269\u7279\u6027\u3092\u6301\u3064634\u3092\u3055\u3089\u306b\u30c7\u30ea\u30b9\u30af\u3059\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u6b21\u306b\u300112\u6b73\u4ee5\u4e0a\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u8a66\u9a13\u3067\u3001\u5e74\u672b\u307e\u3067\u306b\u65b0\u305f\u306a\u30c8\u30ea\u30d7\u30eb\u767b\u9332\u304c\u5b8c\u4e86\u3059\u308b\u5834\u5408\u3001\u89e3\u6790\u6642\u9593\u3092\u8003\u616e\u3057\u3066\u30c8\u30c3\u30d7\u30e9\u30a4\u30f3\u30c7\u30fc\u30bf\u3092\u671f\u5f85\u3067\u304d\u308b\u6642\u671f\u3092\u4e88\u60f3\u3067\u304d\u307e\u3059\u304b\uff1f\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002<\/p>\n

Reshma Kewalramani — \u6700\u9ad8\u7d4c\u55b6\u8cac\u4efb\u8005\u517c\u793e\u9577<\/p>\n

\u305d\u3046\u3067\u3059\u306d\u3002Jessica\u3055\u3093\u3001\u65b0\u3057\u30443\u5264\u4f75\u7528\u7642\u6cd5\u3001Vanzacaftor\u306e3\u5264\u4f75\u7528\u7642\u6cd5\u3001\u3064\u307e\u308a121-561 tezacaftor\u3067\u3059\u304c\u3001\u3053\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u767b\u9332\u306f\u300112+\u306e\u4e21\u8a66\u9a13\u3068\u3082\u5e74\u5185\u306b\u5b8c\u4e86\u3059\u308b\u3068\u4e88\u60f3\u3057\u3066\u3044\u307e\u3059\u3002\u3061\u306a\u307f\u306b\u3001\u3053\u308c\u3089\u306e\u8a66\u9a13\u306e\u671f\u9593\u306f1\u5e74\u3067\u3059\u3002\u3067\u3059\u304b\u3089\u3001\u6765\u5e74\u306e\u3042\u308b\u6642\u70b9\u3067\u3059\u3079\u3066\u306e\u6295\u4e0e\u304c\u5b8c\u4e86\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u5c11\u3057\u6642\u9593\u306f\u304b\u304b\u308a\u307e\u3059\u304c\u3001\u8a66\u9a13\u306e\u7d42\u4e86\u3068\u305d\u306e\u5f8c\u306e\u7d50\u679c\u306b\u3064\u3044\u3066\u306f\u3001\u304b\u306a\u308a\u8fc5\u901f\u306b\u5bfe\u5fdc\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u91cd\u8981\u306a\u306e\u306f\u3001\u6cbb\u7642\u671f\u9593\u304c1\u5e74\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002864\u8a08\u753b\u3068AATD\u306b\u95a2\u3057\u3066\u3001\u79c1\u305f\u3061\u304c\u672c\u5f53\u306b\u9054\u6210\u3057\u3088\u3046\u3068\u3057\u3066\u3044\u308b\u3053\u3068\u306f\u4f55\u3067\u3057\u3087\u3046\u304b\uff1f\u3053\u3053\u3067\u91cd\u8981\u306a\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002864\u3067\u306f\u3001\u4f4e\u5206\u5b50\u88dc\u6b63\u85ac\u3067\u521d\u3081\u3066\u3001AAT\u306e\u6a5f\u80fd\u30ec\u30d9\u30eb\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u6cbb\u7642\u52b9\u679c\u306e\u5927\u304d\u3055\u306f\u3001\u7b2c3\u76f8\u8a66\u9a13\u306b\u79fb\u884c\u3059\u308b\u306b\u306f\u4e0d\u5341\u5206\u3067\u3057\u305f\u304c\u3001\u751f\u7269\u5b66\u7684\u6d3b\u6027\u3092\u8a3c\u660e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002864\u306e\u809d\u81d3\u3067\u306e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3092\u8abf\u3079\u305f\u3044\u306e\u306f\u3001\u7b2c2\u76f8\u8a66\u9a13\u306e\u4e8b\u5f8c\u5206\u6790\u3067\u8840\u6e05\u30dd\u30ea\u30de\u30fc\u30ec\u30d9\u30eb\u304c90\uff05\u4f4e\u4e0b\u3057\u305f\u3053\u3068\u304b\u3089\u3001\u9577\u671f\u9593\u306e\u6cbb\u7642\u3067\u672c\u5f53\u306b\u809d\u81d3\u3067\u306e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u304c\u5f97\u3089\u308c\u308b\u3068\u8003\u3048\u305f\u304b\u3089\u3067\u3059\u3002\u3053\u308c\u304c\u3001\u79c1\u305f\u3061\u304c\u691c\u8a3c\u3057\u3066\u3044\u308b\u4eee\u8aac\u3067\u3059\u3002\u307e\u305f\u3001\u9577\u671f\u9593\u306e\u6cbb\u7642\u304c\u6a5f\u80fd\u6027AAT\u306e\u4e0a\u6607\u306b\u3064\u306a\u304c\u308b\u304b\u3069\u3046\u304b\u3082\u8a55\u4fa1\u3059\u308b\u3064\u3082\u308a\u3067\u3059\u3002<\/p>\n

864\u306f\u3001\u3053\u306e\u9577\u671f\u7684\u306a\u6cbb\u7642\u306b\u57fa\u3065\u3044\u3066\u3001\u958b\u767a\u306e\u5f8c\u671f\u6bb5\u968e\u306b\u9032\u3080\u5206\u5b50\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u306f\u3044\u3001\u305d\u306e\u53ef\u80fd\u6027\u306f\u3042\u308a\u307e\u3059\u3002VX-634\u304c\u3001\u3088\u308a\u5f37\u529b\u3067\u85ac\u5264\u3068\u3057\u3066\u306e\u7279\u6027\u304c\u512a\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u9078\u629e\u3055\u308c\u308b\u5206\u5b50\u3067\u3042\u308b\u53ef\u80fd\u6027\u306f\u3042\u308a\u307e\u3059\u304b\uff1f\u306f\u3044\u3001\u305d\u306e\u53ef\u80fd\u6027\u306f\u3042\u308a\u307e\u3059\u3002\u3060\u304b\u3089\u3053\u305d\u3001\u79c1\u305f\u3061\u306f\u3053\u306e2\u3064\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u4e26\u884c\u3057\u3066\u9032\u3081\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u6700\u7d42\u7684\u306b\u3001\u304a\u305d\u3089\u304f\u6700\u3082\u91cd\u8981\u306a\u3053\u3068\u306f\u3001AATD\u3068\u3044\u3046\u75c5\u6c17\u306b\u5bfe\u3059\u308b\u4f4e\u5206\u5b50\u5316\u5408\u7269\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u3001\u3053\u306e\u75c5\u6c17\u306e\u809d\u81d3\u3068\u80ba\u306e\u4e21\u65b9\u306e\u75c7\u72b6\u3092\u6cbb\u7642\u3067\u304d\u308b\u53ef\u80fd\u6027\u3092\u79d8\u3081\u305f\u552f\u4e00\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n

\u305d\u3057\u3066\u3001\u79c1\u305f\u3061\u304c\u5c0e\u304d\u51fa\u3057\u305f\u3053\u306e\u7d4c\u8def\u306b\u3088\u3063\u3066\u3001\u305d\u306e\u4e21\u65b9\u3092\u4e26\u884c\u3057\u3066\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u3059\u3002<\/p>\n

Jessica Fye — J.P.\u30e2\u30eb\u30ac\u30f3 — \u30a2\u30ca\u30ea\u30b9\u30c8<\/p>\n

\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002<\/p>\n

\u30aa\u30da\u30ec\u30fc\u30bf\u30fc<\/p>\n

\u6b21\u306e\u8cea\u554f\u306f\u30d0\u30f3\u30af\u30fb\u30aa\u30d6\u30fb\u30a2\u30e1\u30ea\u30ab\u306e\u30b8\u30a7\u30d5\u30fb\u30df\u30fc\u30c1\u30e3\u30e0\u304b\u3089\u3067\u3059\u3002\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

\u767a\u8a00\u8005\u4e0d\u660e<\/p>\n

\u30b8\u30a7\u30d5\u306b\u4ee3\u308f\u3063\u3066\u30b8\u30e7\u30fc\u3067\u3059\u3002\u30a8\u30af\u30b5\u30bb\u30eb\u306b\u3064\u3044\u3066\u8cea\u554f\u3067\u3059\u3002\u6700\u7d42\u7684\u306a\u5546\u696d\u5c55\u958b\u306b\u3064\u3044\u3066\u3001\u3069\u306e\u3088\u3046\u306b\u8003\u3048\u308b\u3079\u304d\u304b\u3092\u6559\u3048\u3066\u304f\u3060\u3055\u3044\u3002\u307e\u305f\u3001EU\u3068\u7c73\u56fd\u3067\u7533\u8acb\u3057\u305f\u5f8c\u3001\u6700\u521d\u306e\u53ce\u76ca\u304c\u51fa\u308b\u307e\u3067\u306e\u304a\u304a\u3088\u305d\u306e\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u306f\u3069\u306e\u7a0b\u5ea6\u3067\u3057\u3087\u3046\u304b\uff1f2023\u5e74\u5f8c\u534a\u3068\u8003\u3048\u3066\u3044\u3044\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u305d\u308c\u3068\u30822024\u5e74\u521d\u982d\u3067\u3057\u3087\u3046\u304b\uff1f\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

Reshma Kewalramani — \u6700\u9ad8\u7d4c\u55b6\u8cac\u4efb\u8005\u517c\u793e\u9577<\/p>\n

\u307e\u305a\u3001\u73fe\u5728\u306e\u72b6\u6cc1\u3068\u3001\u305d\u308c\u306b\u5411\u3051\u3066\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\u76f4\u8fd1\u306e\u30de\u30a4\u30eb\u30b9\u30c8\u30fc\u30f3\u304b\u3089\u304a\u8a71\u3057\u3057\u307e\u3059\u3002\u6b21\u306b\u3001\u767a\u58f2\u524d\u306e\u6d3b\u52d5\u306b\u3064\u3044\u3066\u3001\u30b9\u30c1\u30e5\u30a2\u30fc\u30c8\u306b\u30b3\u30e1\u30f3\u30c8\u3092\u6c42\u3081\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u73fe\u5728\u3001\u79c1\u305f\u3061\u306fEU\u3001\u82f1\u56fd\u3001\u7c73\u56fd\u3078\u306e\u88fd\u54c1\u51fa\u8377\u306b\u6ce8\u529b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u7c73\u56fd\u3067\u306f\u6765\u670811\u6708\u306b\u30ed\u30fc\u30ea\u30f3\u30b0\u7533\u8acb\u3092\u958b\u59cb\u3057\u3001EU\u3068\u82f1\u56fd\u3067\u306f\u4eca\u5e74\u672b\u307e\u3067\u306b\u7533\u8acb\u3092\u5b8c\u4e86\u3067\u304d\u308b\u3088\u3046\u3001\u9806\u8abf\u306b\u63a8\u79fb\u3057\u3066\u3044\u307e\u3059\u3002\u30b9\u30c1\u30e5\u30a2\u30fc\u30c8\u3001\u305d\u3053\u304b\u3089\u4e0a\u5e02\u524d\u306e\u6d3b\u52d5\u306b\u3064\u3044\u3066\u5c11\u3057\u304a\u8a71\u3044\u305f\u3060\u3051\u307e\u3059\u304b\uff1f<\/p>\n

Stuart Arbuckle — \u6700\u9ad8\u57f7\u884c\u8cac\u4efb\u8005\uff08COO<\/p>\n

1\u3064\u306f\u653f\u7b56\u7acb\u6848\u8005\u3068\u652f\u6255\u8005\u3001\u3082\u30461\u3064\u306f\u3001\u652f\u6255\u8005\u3084\u653f\u7b56\u7acb\u6848\u8005\u3068\u30a8\u30af\u30b5\u30bb\u30eb\u3092\u5b9f\u969b\u306b\u7ba1\u7406\u3059\u308b\u3053\u3068\u306b\u306a\u308b\u516c\u8a8d\u6cbb\u7642\u30bb\u30f3\u30bf\u30fc\u3068\u306e\u95a2\u4fc2\u3067\u3059\u3002\u3054\u60f3\u50cf\u306e\u3068\u304a\u308a\u3001\u898f\u5236\u5f53\u5c40\u306e\u627f\u8a8d\u3092\u5f85\u3063\u3066\u3001\u60a3\u8005\u3055\u3093\u304c\u3067\u304d\u308b\u3060\u3051\u65e9\u304f\u30a8\u30ad\u30b5\u30bb\u30eb\u3092\u5229\u7528\u3067\u304d\u308b\u3088\u3046\u3001\u9069\u5207\u306a\u6761\u4ef6\u3092\u6574\u3048\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u3053\u306e\u75be\u60a3\u306f\u3001\u30a2\u30f3\u30e1\u30c3\u30c8\u30cb\u30fc\u30ba\u304c\u9ad8\u304f\u3001\u652f\u6255\u8005\u3084\u653f\u7b56\u7acb\u6848\u8005\u306e\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\u306b\u3088\u3063\u3066\u5341\u5206\u306b\u8a8d\u8b58\u3055\u308c\u3066\u3044\u308b\u75be\u60a3\u3067\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u5f7c\u3089\u3068\u306e\u8a71\u3057\u5408\u3044\u306f\u975e\u5e38\u306b\u751f\u7523\u7684\u3067\u5b9f\u308a\u591a\u3044\u3082\u306e\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u8a8d\u5b9a\u6cbb\u7642\u65bd\u8a2d\u306b\u3064\u3044\u3066\u306f\u3001\u60a3\u8005\u3055\u3093\u304c\u96c6\u4e2d\u3057\u3066\u3044\u308b\u5834\u6240\u306e\u8fd1\u304f\u306b\u3042\u308b\u8a8d\u5b9a\u6cbb\u7642\u65bd\u8a2d\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u7c73\u56fd\u3067\u306f\u3001\u7d0425\u306e\u5dde\u306b\u60a3\u8005\u3055\u3093\u304c\u96c6\u4e2d\u3057\u3066\u304a\u308a\u3001\u60a3\u8005\u3055\u3093\u306e\u7d0490\uff05\u304c\u3053\u306e\u5730\u57df\u306b\u3044\u307e\u3059\u3002EU\u3067\u306f\u3001\u30a4\u30ae\u30ea\u30b9\u3001\u30d5\u30e9\u30f3\u30b9\u3001\u30a4\u30bf\u30ea\u30a2\u3001\u30c9\u30a4\u30c4\u306e4\u30ab\u56fd\u306b\u7d0475\uff05\u306e\u60a3\u8005\u3055\u3093\u304c\u3044\u307e\u3059\u3002<\/p>\n

\u305d\u3053\u3067\u3001\u7c73\u56fd\u306b\u7d0450\u30ab\u6240\u3001\u6b27\u5dde\u306e4\u30ab\u56fd\u306b\u7d0425\u30ab\u6240\u306e\u6cbb\u7642\u30bb\u30f3\u30bf\u30fc\u3092\u8a2d\u7acb\u3057\u3001\u898f\u5236\u5f53\u5c40\u306e\u627f\u8a8d\u304c\u5f97\u3089\u308c\u308c\u3070\u3001\u5927\u534a\u306e\u60a3\u8005\u3055\u3093\u306b\u5bfe\u5fdc\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u7e70\u308a\u8fd4\u3057\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u79c1\u305f\u3061\u306e\u65bd\u8a2d\u3068\u306e\u95a2\u308f\u308a\u306f\u975e\u5e38\u306b\u30dd\u30b8\u30c6\u30a3\u30d6\u306a\u3082\u306e\u3067\u3057\u305f\u3002\u5f7c\u3089\u306f\u660e\u3089\u304b\u306b\u3001\u60a3\u8005\u306b1\u56de\u9650\u308a\u306e\u6a5f\u80fd\u7684\u6cbb\u7652\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u3092\u79d8\u3081\u305f\u30a8\u30af\u30b5\u30bb\u30eb\u306e\u3088\u3046\u306a\u3082\u306e\u306e\u53ef\u80fd\u6027\u306b\u975e\u5e38\u306b\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u767a\u8a00\u8005\u4e0d\u660e<\/p>\n

\u7d20\u6674\u3089\u3057\u3044\u3002\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u30b9\u30fc\u30b8\u30fc\u30ea\u30b6 — \u6295\u8cc7\u5bb6\u5411\u3051\u5e83\u5831\u62c5\u5f53\u4e0a\u7d1a\u526f\u793e\u9577<\/p>\n

\u3042\u30681\u56de\u3060\u3051\u6642\u9593\u3092\u304f\u3060\u3055\u3044\u3002<\/p>\n

\u30aa\u30da\u30ec\u30fc\u30bf\u30fc<\/p>\n

\u6b21\u306e\u8cea\u554f\u306fUBS\u306e\u30b3\u30ea\u30f3\u30fb\u30d6\u30ea\u30b9\u30c8\u30a6\u304b\u3089\u3067\u3059\u3002\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

\u767a\u8a00\u8005\u4e0d\u660e<\/p>\n

\u3053\u3093\u306b\u3061\u306f\u3001\u30b3\u30ea\u30f3\u306e[Inaudible]\u3067\u3059\u3002\u3054\u8cea\u554f\u3092\u3044\u305f\u3060\u304d\u307e\u3057\u3066\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002\u305d\u3053\u3067\u30012\u3064\u306e\u8cea\u554f\u3092\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002\u307e\u305a1\u3064\u76ee\u306f\u3001\u5fa1\u793e\u306eCF\u30d9\u30fc\u30b9\u306e\u30d3\u30b8\u30cd\u30b9\u306b\u3064\u3044\u3066\u3067\u3059\u3002<\/p>\n

\u30a2\u30c3\u30f4\u30a3\u306e\u30c6\u30b6\u30ab\u30d5\u30c8\u30fc\u30eb\u306b\u3088\u308b\u6700\u65b0\u306e3\u5264\u4f75\u7528\u7642\u6cd5\u304cclinicaltrials.gov\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u7af6\u4e89\u4e0a\u306e\u8105\u5a01\u3092\u3069\u306e\u3088\u3046\u306b\u304a\u8003\u3048\u3067\u3057\u3087\u3046\u304b\uff1f2\u3064\u76ee\u306e\u8cea\u554f\u306f\u3001CRISPR\u3092\u7528\u3044\u305fDMD\u6cbb\u7642\u85ac\u306b\u3064\u3044\u3066\u3067\u3059\u3002IND\u7533\u8acb\u306f\u6765\u5e74\u306b\u306a\u308b\u3068\u306e\u3053\u3068\u3067\u3059\u304c\u3001\u3044\u3064\u3054\u308d\u306b\u306a\u308b\u3068\u304a\u8003\u3048\u3067\u3059\u304b\uff1f\u3067\u306f\u3001\u3053\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u6700\u521d\u306e\u81e8\u5e8a\u30c7\u30fc\u30bf\u306f\u3044\u3064\u9803\u898b\u3089\u308c\u308b\u3068\u304a\u8003\u3048\u3067\u3059\u304b\uff1f\u4f8b\u3048\u3070\u3001\u7cd6\u5c3f\u75c5\u306eVX-880\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u3088\u3046\u306b\u3001\u5358\u4e00\u60a3\u8005\u30c7\u30fc\u30bf\u3092\u516c\u958b\u3059\u308b\u3088\u3046\u306a\u3053\u3068\u306f\u304a\u8003\u3048\u3067\u3057\u3087\u3046\u304b\uff1f\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

Reshma Kewalramani — \u6700\u9ad8\u7d4c\u55b6\u8cac\u4efb\u8005\u517c\u793e\u9577<\/p>\n

\u8cea\u554f\u304c2\u3064\u3042\u308a\u307e\u3059\u3002\u3072\u3068\u3064\u306fCF\u306b\u3064\u3044\u3066\u3001\u3082\u3046\u3072\u3068\u3064\u306fDMD\u306b\u3064\u3044\u3066\u3067\u3059\u3002\u307e\u305a\u3001DMD\u306e\u8cea\u554f\u3092\u304a\u53d7\u3051\u3057\u307e\u3059\u3002\u307e\u305a\u3001\u7686\u3055\u3093\u306b\u7c21\u5358\u306a\u80cc\u666f\u3092\u8aac\u660e\u3057\u307e\u3059\u3002<\/p>\n

DMD\u306b\u5bfe\u3059\u308b\u79c1\u305f\u3061\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u30de\u30a4\u30af\u30ed\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30f3\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u4ed6\u306e\u591a\u304f\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u306f\u7570\u306a\u308b\u3053\u3068\u3092\u601d\u3044\u51fa\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u79c1\u305f\u3061\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u30a8\u30ad\u30bd\u30f3\u30b9\u30ad\u30c3\u30d4\u30f3\u30b0\u3092\u4e2d\u5fc3\u3068\u3057\u305fin vivo\u907a\u4f1d\u5b50\u7de8\u96c6\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3042\u308a\u3001\u5b8c\u5168\u9577\u3001\u3042\u308b\u3044\u306f\u305d\u308c\u306b\u8fd1\u3044\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30f3\u3092\u7523\u751f\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u305d\u3057\u3066\u3001\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u4fe1\u3058\u308b\u7406\u7531\u306f\u3001\u79c1\u305f\u3061\u304c\u76ee\u306b\u3059\u308b\u30d2\u30c8\u306e\u907a\u4f1d\u5b66\u7684\u7279\u5fb4\u306b\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30d9\u30c3\u30ab\u30fc\u578b\u7b4b\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc\u3067\u306f\u3001\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30f3\u304c\u307b\u307c\u5168\u9577\u3067\u3042\u308b\u305f\u3081\u3001\u3053\u306e\u75c5\u6c17\u306fDMD\u306e\u4e2d\u3067\u3082\u304b\u306a\u308a\u8efd\u75c7\u306e\u90e8\u985e\u306b\u5165\u308a\u307e\u3059\u3002<\/p>\n

\u30de\u30a4\u30af\u30ed\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30f3\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u306f\u3001\u3053\u306e\u3088\u3046\u306a\u30d2\u30c8\u306e\u907a\u4f1d\u5b66\u7684\u306a\u80cc\u666f\u304c\u306a\u3044\u306e\u3067\u3059\u3002\u79c1\u306f\u3001\u3053\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u9032\u5c55\u306b\u3068\u3066\u3082\u6e80\u8db3\u3057\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001IND\u53d6\u5f97\u3092\u76ee\u6307\u3057\u305f\u8a66\u9a13\u3092\u884c\u3063\u3066\u3044\u308b\u3068\u3053\u308d\u3067\u3059\u3002\u73fe\u5728\u3001\u6cbb\u9a13\u85ac\u88fd\u9020\u8a31\u53ef\u7533\u8acb\u306e\u305f\u3081\u306e\u8a66\u9a13\u3092\u884c\u3063\u3066\u304a\u308a\u3001\u6765\u5e74\u306b\u306f\u5b8c\u4e86\u3057\u3001\u6cbb\u9a13\u85ac\u88fd\u9020\u8a31\u53ef\u7533\u8acb\u3092\u884c\u3046\u4e88\u5b9a\u3067\u3059\u3002<\/p>\n

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\u79c1\u305f\u3061\u306e\u624b\u304c\u6c17\u306b\u5165\u3063\u305f\u306e\u3067\u3001\u3055\u3089\u306a\u308b\u30c7\u30fc\u30bf\u3092\u5171\u6709\u3059\u308b\u3053\u3068\u3092\u697d\u3057\u307f\u306b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30aa\u30da\u30ec\u30fc\u30bf\u30fc<\/p>\n

\u3053\u308c\u3067\u8cea\u7591\u5fdc\u7b54\u306f\u7d42\u4e86\u3067\u3059\u3002\u6700\u5f8c\u306b\u3001\u30b9\u30fc\u30b8\u30fc\u30fb\u30ea\u30b5\u3055\u3093\u306b\u9589\u4f1a\u306e\u8f9e\u3092\u304a\u9858\u3044\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

\u30b9\u30fc\u30b8\u30fc\u30ea\u30b6 — \u30a4\u30f3\u30d9\u30b9\u30bf\u30fc\u30ea\u30ec\u30fc\u30b7\u30e7\u30f3\u30ba\u62c5\u5f53\u4e0a\u7d1a\u526f\u793e\u9577<\/p>\n

\u30c1\u30e3\u30c3\u30af\u3001\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u307f\u306a\u3055\u3093\u304b\u3089\u306e\u3054\u8cea\u554f\u3082\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u8cea\u554f\u3092\u304a\u5bc4\u305b\u3044\u305f\u3060\u3044\u305f\u7686\u69d8\u3001\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

 <\/p>\n

\u4ee5\u4e0a\u3067\u3059\u3002\u4ed6\u306e\u7ffb\u8a33\u5e0c\u671b\u3084\u3054\u611f\u60f3\u3092\u3044\u305f\u3060\u3051\u308b\u3068\u5b09\u3057\u3044\u3067\u3059\u3002<\/p>\n

\uff0a\u8aa4\u8a33\u306a\u3069\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3067\u306e\u53c2\u8003\u7a0b\u5ea6\u306b\u3057\u3066\u3044\u305f\u3060\u304d\u6295\u8cc7\u306f\u81ea\u5df1\u5224\u65ad\u3067\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n

\u30d6\u30ed\u30b0\u904b\u55b6\u306e\u52b1\u307f\u306b\u306a\u308a\u307e\u3059\u306e\u3067\u3001\u304a\u624b\u6570\u3067\u3059\u304c\u3001\u5fdc\u63f4\u306e\uff11\u65e5\uff11\u30af\u30ea\u30c3\u30af\u3092\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u81f4\u3057\u307e\u3059\u3002<\/p>\n

\u2193\u2193\uff1c\u5fdc\u63f4\u30af\u30ea\u30c3\u30af\u304a\u9858\u3044\u3057\u307e\u3059\uff1e<\/p>\n

\"\u306b\u307b\u3093\u30d6\u30ed\u30b0\u6751<\/a>
\n\u306b\u307b\u3093\u30d6\u30ed\u30b0\u6751<\/a><\/p>\n

\"\u306b\u307b\u3093\u30d6\u30ed\u30b0\u6751<\/a>
\n\u306b\u307b\u3093\u30d6\u30ed\u30b0\u6751<\/a><\/p>\n

\"\u306b\u307b\u3093\u30d6\u30ed\u30b0\u6751<\/a>
\n\u306b\u307b\u3093\u30d6\u30ed\u30b0\u6751<\/a><\/p>\n

\"\u306b\u307b\u3093\u30d6\u30ed\u30b0\u6751<\/a>
\n\u306b\u307b\u3093\u30d6\u30ed\u30b0\u6751<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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<\/p>\n","protected":false},"author":1,"featured_media":1477,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[72],"tags":[632,633,348,793,83,285],"class_list":{"0":"post-2117","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-72","8":"tag-vrtx","9":"tag-633","10":"tag-348","11":"tag-793","12":"tag-83","13":"tag-285"},"yoast_head":"\n\u30d0\u30fc\u30c6\u30c3\u30af\u30b9\u30fb\u30d5\u30a1\u30fc\u30de\u30b7\u30e5\u30fc\u30c6\u30a3\u30ab\u30eb\u30ba(VRTX)2022\u5e74\u7b2c3\u56db\u534a\u671f\u6c7a\u7b97\u8aac\u660e\u4f1a – \u682a\u5f0f\u6295\u8cc7\u30921up\u3059\u308b\u30d6\u30ed\u30b0<\/title>\n<meta name=\"description\" content=\"\u30d0\u30fc\u30c6\u30c3\u30af\u30b9\u30fb\u30d5\u30a1\u30fc\u30de\u30b7\u30e5\u30fc\u30c6\u30a3\u30ab\u30eb\u30ba(VRTX)2022\u5e74\u7b2c3\u56db\u534a\u671f\u6c7a\u7b97\u8aac\u660e\u4f1a\u306e\u65e5\u672c\u8a9e\u8a33\u3067\u3059\u3002\u597d\u6c7a\u7b97\u3067\u682a\u4fa1\u3082\u6025\u4f38\u3067\u3059\u306d\u3002\u682a\u4fa1\u306f\u524d\u56de\u306e\u9ad8\u5024\u3092\u30d6\u30ec\u30a4\u30af\u30a2\u30a6\u30c8\u3057\u305f\u306e\u3067\u8cb7\u3044\u6642\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/1up-life.blog\/?p=2117\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" 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